宫颈鳞癌中survivin的表达与紫杉醇疗效的相关性研究  

Correlation between expression of survivin or its change after chemotherapy and the effect of paclitaxel in cervical squamous cell carcinoma

作　　者：张芸中[1] 叶世勤[1] 李晓琴[2] 

机构地区：[1]兰州大学第二医院妇科,甘肃兰州730000 [2]甘肃省肿瘤医院病理科,甘肃兰州730050

出　　处：《甘肃医药》2012年第7期481-483,共3页Gansu Medical Journal

摘　　要：目的:探讨宫颈鳞癌中survivin的表达及化疗前后表达水平的变化与紫杉醇疗效的关系。方法:应用免疫组化方法检测52例新辅助化疗前后宫颈鳞癌组织survivin的表达情况,分析其与紫杉醇化疗疗效的关系。结果:全组病例化疗前后survivin阳性率67.3%(35/52)和55.8%(29/52),无统计学差异(P>0.05);survivin表达与宫颈鳞癌的临床分期、分化程度及患者年龄均无明显相关性,(P>0.05)。全组完全缓解10例(19.2%),部分缓解37例(71.2%),总缓解率为90.4%(47/52)。其中病理完全缓解7例(13.5%)。化疗前survivin强阳性组化疗有效率63.6%(7/11)明显低于survivin阴性组100%(17/17)或survivin弱阳性组95.8%(23/24),差异有统计学意义(P<0.05)。结论:化疗前宫颈癌组织中survivin阳性表达强度和化疗后阳性表达下降程度可能与化疗敏感性密切相关,survivin可能作为一项预测紫杉醇疗效的新指标。Objective：To study the expression of survivin and the correlation between its change after chemotherapy and the effect of pachtaxel in cervical squamous cell carcinoma. Methods： Using immunohistochemical method to detect the expression of survivin for prc-and post- neoadjuvant chemotherapy in 52 cases of cervical squamous cell carcinoma. The response to the treatment was evaluated. Results： Positive rates of survivin for all cases pre-and post-chemotherapy group were 67.3%（35/52） and 55.8%（29/52） respectively （P〉0.05）. There was no obvious relation of survivin expression for cervical squamous cell earoinomin with age, clinical phase and the degree of differentiation （P〉 0.05）.Of the 52 patients, 10 （19.2%） showed a complete response, 37 （71.2%）had a partial response to chemotherapy, making an overall response rate of 90.4%（47/52）, and among them （13.5%） pathological CR were identified.The patients with negative 100%（17/17） or weak positive survivin 95.8%（23/24 ） presented better effect of neoadjuvant chemotherapy than those with intense survivin 63.6%（7/11 ）, and the difference was significant（P〈0.05）. Conclusion： There may be closely relation for chemical sensitivity between survivin expression strength for pre-neoadjuvant chemotherapy and a drop of expression for post-chemotherapy. The survivin might be a valuable new indicator in predicting the sensitivity of paclitaxel.

关 键 词：宫颈鳞癌 新辅助化疗 SURVIVIN 紫杉醇 

分 类 号：R734.201[医药卫生—肿瘤]