High Sensitivity C-Reactive Protein Associated with Different Health Predictors in Middle-Aged and oldest old Chinese  

作　　者：ZHAI Yi SHI Xiao Ming FITZGERALD Simon Michael QIAN Han Zhu KRAUS Virginia B SERENY Melanie HU Perry YIN Zhao Xue XU Jian Wei ZENG Yi 

机构地区：[1]Chinese Center for Disease Control and Prevention, Beijing 102206, China [2]SUNY Downstate College of Medicine, NY 11218, USA [3]Division of Epidemiology, Vanderbilt University School of Medicine, TN 37203-1738, USA [4]Department of Sociology, Duke University, Durham, NC, 27708, USA [5]Department ofSociology,Duke University, Durham, NC, 27708, USA [6]Ronald Reagan UCLA Medical Center, Los Angeles, CA90095,USA [7]Center for the Study of Aging and Human Development and Geriatric Division of Medical SchoolDuke University, Box 3003, Room 1506, BUSSE Building, Durham, NC27710, USA [8]China Center for EconomicResearch, National School of Development at Peking University, Beij'ing 100087, China

出　　处：《Biomedical and Environmental Sciences》2012年第3期257-266,共10页生物医学与环境科学（英文版）

基　　金：supported by National Natural Science Founda on of China (70533010);NIH grant # 5R24 TW 007988;the Fogarty Interna onal Clinical Research Scholars Support Center at Vanderbilt-AAMC

摘　　要：Objective To describe the distribution of plasma high sensitivity C-reactive protein （hsCRP） and explore the relationship between hsCRP and metabolic risk factors among residents living in longevity areas of China. Methods 268 individuals aged between 40 and 59 years and 506 individuals aged over 90 years were selected from 5 longevity areas of China to participate in a cross section longitudinal cohort study. The participants were interviewed with general health related questionnaire to collect their demographic, behavioral and lifestyle data, as well as their chronic conditions, and meanwhile their physical and biomedical parameters including waist circumference （WC）, blood pressure （BP）, hsCRP, plasma lipids, and fasting blood glucose （FBG） were measured. Results The median of hsCRP was 0.99 mg/L in the middle-aged group and 2.76 mg/L in the oldest old group. No significant gender difference was observed between the above two groups. Among the oldest old individuals, 36.56% had an hsCRP level 〉3.0 mg/L. The prevalence of high hsCRP was 26.79% in the middle-aged group. The results of stepwise multiple linear regression analyses showed that HDL-C was independently associated with In （hsCRP） concentration in the middle-aged group, whereas In （TG）, HDL-C and FBG were correlated after adjustment for gender, study site, smoking, drinking, education and BMI in the oldest old group. Conclusion HDL-C is a stronger predictor of elevated hsCRP than other metabolic factors in the middle-aged population. For the oldest old persons, high TG, low HDL-C, and FBG predict elevated plasma hsCRP.Objective To describe the distribution of plasma high sensitivity C-reactive protein （hsCRP） and explore the relationship between hsCRP and metabolic risk factors among residents living in longevity areas of China. Methods 268 individuals aged between 40 and 59 years and 506 individuals aged over 90 years were selected from 5 longevity areas of China to participate in a cross section longitudinal cohort study. The participants were interviewed with general health related questionnaire to collect their demographic, behavioral and lifestyle data, as well as their chronic conditions, and meanwhile their physical and biomedical parameters including waist circumference （WC）, blood pressure （BP）, hsCRP, plasma lipids, and fasting blood glucose （FBG） were measured. Results The median of hsCRP was 0.99 mg/L in the middle-aged group and 2.76 mg/L in the oldest old group. No significant gender difference was observed between the above two groups. Among the oldest old individuals, 36.56% had an hsCRP level 〉3.0 mg/L. The prevalence of high hsCRP was 26.79% in the middle-aged group. The results of stepwise multiple linear regression analyses showed that HDL-C was independently associated with In （hsCRP） concentration in the middle-aged group, whereas In （TG）, HDL-C and FBG were correlated after adjustment for gender, study site, smoking, drinking, education and BMI in the oldest old group. Conclusion HDL-C is a stronger predictor of elevated hsCRP than other metabolic factors in the middle-aged population. For the oldest old persons, high TG, low HDL-C, and FBG predict elevated plasma hsCRP.

关 键 词：High-sensitivity C-reactive protein Blood lipids Fasting blood glucose MIDDLE-AGED Oldestold individuals LONGEVITY China 

分 类 号：Q51[生物学—生物化学] X503.1[环境科学与工程—环境工程]