温肾益心丹对慢性心力衰竭老年患者心肌细胞凋亡的影响  

Effects of Wenshenyixin Pellet on Myocardial Cell Apoptosis in Old Patients with Chronic Heart Failure

作　　者：杜卫甫[1] 胡业彬[1] 张叶祥[1] 程晓昱[1] 何佳[1] 

机构地区：[1]安徽省中医院,安徽合肥230031

出　　处：《中国中医急症》2012年第7期1053-1054,共2页Journal of Emergency in Traditional Chinese Medicine

基　　金：安徽中医学院第一附属医院临床科研项目(2008LCKY016)

摘　　要：目的观察温肾益心丹联合西医常规治疗对老年慢性心力衰竭(CHF)患者心肌细胞凋亡的影响。方法 50例CHF患者随机分为对照组和研究组,对照组予西医常规治疗,研究组在西医常规治疗基础上加服温肾益心丹(每次3粒,每日3次),疗程均为28 d。治疗前后采集血液标本,应用酶联免疫法测定血清中sFas、sFasL水平。结果研究组治疗后血清中sFas、sFasL水平明显下降,对照组治疗后血清中sFas、sFasL水平也下降,但较治疗前无明显差异。两组治疗后比较,研究组血清中sFas、sFasL水平下降更显著。结论温肾益心丹能较好地降低CHF患者血清中凋亡相关因子sFas、sFasL的水平,可能是其发挥作用的机制之一。Objective： To observe the effects of Wenshenyixin Pellet associated with routine western medicine therapy on myocardial cell apoptosis in old patients with chronic heart failure（CHF）.Methods： 50 patients with CHF were randomly divided into 2 groups.The control group（25 cases） was treated with conventional western medicine including digitalin,diuretic,angiotensin converting enzyme inhibitor and so on.The research group（25 cases） was added with Wenshenyixin Pellet on the routine western medicine therapy.The therapeutic course was 4 weeks in each group.Levels of soluble Fas（sFas）and soluble Fas Ligand（sFasL） in serum were measured by enzyme linked immunoadsorbent assay（ELISA）.Results： In research group,the levels of sFas and sFasL in serum were significantly decreased after treatment.Meanwhile,in the control group,levels of sFas and sFasL in serum were decreased.However,there were no statistical differences before and after treatment in the control group.The decline degrees of the treatment group were more obvious than those of the control group.Conclusion： Wenshenyixin Pellet can reduce levels including sFas and sFasL in patients with CHF.Its effect is superior to the western medicines.

关 键 词：温肾益心丹 慢性心力衰竭 细胞凋亡 SFAS SFASL 

分 类 号：R541.61[医药卫生—心血管疾病]