帕瑞昔布钠超前镇痛在阻塞性睡眠呼吸暂停手术中的麻醉临床应用价值分析  

Effects of Preemptive Analgesia with Parecoxib Sodium on Postoperative Pain in Patients with Obstructive Sleep Apnea-Hypopnea Syndrome

作　　者：郝建华[1] 郭正纲[1] 王晓燕[1] 靳恒[1] 

机构地区：[1]中国人民解放军总医院第一附属医院麻醉科,北京100048

出　　处：《河北医学》2012年第8期1052-1054,共3页Hebei Medicine

摘　　要：目的:观察帕瑞昔布钠对于阻塞性睡眠呼吸暂停低通气综合征手术患者的超前镇痛作用。方法:将62例择期行悬雍垂腭咽成形术患者随机分为治疗组和对照组各31例,治疗组术前静脉注射帕瑞昔布钠40 mg;对照组术毕即刻静脉注射帕瑞昔布钠40 mg。采用视觉模拟评分法(VAS)评估患者术后1h、2h、4h、8h、24h疼痛感觉程度,并且观察两组的不良反应。结果:术后8h治疗组VAS评分低于对照组(P<0.05),术后24 h两组间差异无显著性(P>0.05)。结论:术前给予阻塞性睡眠呼吸暂停手术帕瑞昔布钠静脉注射可以产生超前镇痛作用,并且不良反应较小,值得临床推广应用。Objective： To observe the effects of preemptive analgesia with parecoxib sodium on postop- erative pain in patients with obstructive sleep apnea-hypopnea syndrome. Method： 62 cases of patients scheduled for selective uvulopalatopharyngoplasty surgery were randomly divided into treatment group and control group, 31 cases in each group, the treatment group of preoperative intravenous parecoxib sodium 40 mg ; the control group completed the immediate postoperative intravenous parecoxib sodium 40 mg. Postoper-ative visual analog scale （ VAS ） assessment of patients after 1 hours, 2 hours, 4 hours, 8 hours, 24 hours of pain degree, and the adverse reactions were observed in the two groups. Result： After 8 hours of VAS scores in treatment group than in control group （ P 〈 0.05 ） , and 24 hours after operation between the two groups had no significant difference （ P 〉 0.05 ）. Conclusion： Preoperative give obstructive sleep apnea operation of parecoxib sodium intravenous injection can produce preemptive analgesia effects and adverse re-actions, smaller, worthy of clinical application.

关 键 词：帕瑞昔布钠 超前镇痛 阻塞性睡眠呼吸暂停 悬雍垂腭咽成形术 

分 类 号：R614[医药卫生—麻醉学]