无溶剂条件下1-芳甲酰基苯并三氮唑的合成  

Synthesis of 1-arylformylbenzotriazoles under solvent-free conditions

作　　者：谢文林[1] 谢玲[1] 李雪锋 周颖[1] 唐绪福[1] 刘人愿[1] 陈注[1] 

机构地区：[1]湖南科技大学,理论化学与分子模拟教育部重点实验室,分子构效关系湖南省普通高校重点实验室,化学化工学院,湖南湘潭411201 [2]江西东邦药业有限公司,江西宜春330700

出　　处：《湖南科技大学学报（自然科学版）》2012年第2期93-95,共3页Journal of Hunan University of Science And Technology：Natural Science Edition

基　　金：湖南省科技计划项目(2011SK3122);脑功能基因组学教育部重点实验室(10SKBFGK15);理论化学与分子模拟省部共建教育部重点实验室开放课题(LKF0905)

摘　　要：在无溶剂条件下,由苯并三氮唑、取代苯甲酸、二氯亚砜经过室温研磨合成了1-芳甲酰基苯并三氮唑,收率达到了88%～95%,其结构分别用IR,1H NMR和MS进行了表征.此方法具有反应条件温和,操作简单,反应时间短,产率高等优点,是一种有效合成酰基苯并三氮唑的新方法.A series of 1-arylformylbenzotriazoles were synthesized by reaction of benzotriazole and substituted benzoic acid in the presence of thionyl chloride（SOCl2） under solvent-free conditions by grinding at room temperature giving the yields of 88%-95%.The structures of the products were characterized by IR,1H NMR and MS.The procedure offers several advantages including milder reaction conditions,easier work-up,shorter reaction time,and higher yields.It is a novel synthesis method of acylbenzotriazoles.

关 键 词：苯并三氮唑 芳甲酰基苯并三氮唑 无溶剂 合成 

分 类 号：O626.3[理学—有机化学]