壳聚糖微球及壳聚糖-明胶复合物微球的制备及缓释性能研究  

A study on the preparation and sustained-releasing property of chitosan microsphere and chitosan-gelatine complex microsphere

作　　者：曲凤华[1] 栗明献[2] 陈微[3] 李超英[4] 

机构地区：[1]中国石油吉林石化公司研究院,吉林吉林132021 [2]廊坊师范学院化学与材料科学学院,河北廊坊071000 [3]中国石油吉林石化公司聚乙烯厂,吉林吉林132022 [4]中国石油吉林石化公司炼油厂,吉林吉林132022

出　　处：《化工科技》2012年第3期43-48,共6页Science & Technology in Chemical Industry

摘　　要：采用乳化-化学交联法制备壳聚糖微球及壳聚糖-明胶复合物微球,并通过实验确定了最佳的成球条件:即m(壳聚糖)∶m(明胶)=2∶1,span-80用量为10g/100mL,乳化剪切速度为600r/min,交联率为60%,固化时间为40min。该方法制备的壳聚糖微球球形圆滑,粘连度小,亲水性好。此外在对壳聚糖药物缓释的研究基础上,对壳聚糖复合明胶后,对药物缓释的影响情况进行了研究探索。以生物可降解性和生物相容性好的壳聚糖和明胶为载体承载阿司匹林,研制出阿司匹林壳聚糖-明胶微球,为阿司匹林提供了一种理想的缓释载体。In this experiment,the emulsifying-chemical crosslinking method was used to prepare chi tosan microsphere and chitosan-gelatin complex microsphere. Moreover, the optimal condition of spheronization was determined. Under this condition,m（chitosan）：m（gelatin） = 2 ： 1,the amount of Span-80 is 10 g/100 mL,the emulsifying shearing rate is 600 r/min, the cross-linking rate is 60% and the curing time is 40 min. From this method, smooth-sphered, low-tenacity and high-hydrophilic chitosan microsphere was obtained. In addition, on the basic of studying sustained-rdeasing property of chitosan microsphere drugs, a study and exploration of the effect of sustained-release of drugs was also carried out after the combination of chitosan and gelatine. Chitosan and gelatin with high biodegrad ability and biocompatibility were used as the carriers for Aspirin. The study showed that the chitosan-gelatin complex microsphere is a perfect sustained-releasing carrier for Aspirin.

关 键 词：壳聚糖 药物缓释 乳化-化学交联法 明胶 分散剂 交联时间 搅拌速度 

分 类 号：R944[医药卫生—药剂学]