复方薄荷脑滴鼻液的质量控制  

Study on the Quality Control Standard of Compound Menthol Nasal Drops

作　　者：谢军 彭贤东 龙凤 唐志立 

机构地区：[1]四川省南充市中心医院药剂科,四川南充637000

出　　处：《中国药业》2012年第13期27-28,共2页China Pharmaceuticals

摘　　要：目的建立复方薄荷脑滴鼻液的质量标准。方法采用差示分光光度法对樟脑进行定性分析,分别采用旋光度测定法、紫外-可见分光光度法测定其中薄荷脑、樟脑的含量。结果薄荷脑、樟脑检测浓度的线性范围分别为1.0～10.0 g/L(r=0.999 4,n=5),1.0～5.0 g/L(r=0.999 8,n=5);平均回收率分别为99.92%(RSD=1.25%,n=9),99.38%(RSD=1.56%,n=9)。结论所用方法简便、准确、专属性强,可用于复方薄荷脑滴鼻液的质量控制。Objective To establish the quality standard of Compound Menthol Nasal Drops.Methods Camphor was qualitatively detected by differential spectrophotometry.The content of mentholum and camphor was determined by spin photometric determination method and UV spectrophotometry,respectively.Results The linear ranges for mentholum and camphor were 1.0-10.0 g/L（r=0.999 4,n=5）and 1.0-5.0 g/L（r=0.999 8,n=5）,respectively,with average recovery rates of 99.92%（RSD=1.25%,n=9）and 99.38%（RSD=1.56%,n=9）,respectively.Conclusion This method is simple,accurate and specific.It can be used for the quality control of Compound Menthol Nasal Drops.

关 键 词：薄荷脑 樟脑 旋光度测定法 紫外-可见分光光度法 质量控制 

分 类 号：R284.1[医药卫生—中药学] R286.0[医药卫生—中医学]