新型抗抑郁药物的药物相互作用  

Drug interactions of new antidepressants

作　　者：管晓波[1] 陆峥[1] 

机构地区：[1]同济大学附属同济医院精神医学科,上海200065

出　　处：《世界临床药物》2012年第7期395-400,共6页World Clinical Drug

摘　　要：新型抗抑郁药物的联合治疗及其与其他药物的联合应用可引起经细胞色素P450酶介导的多种药物的药动学改变,药物相互作用研究对临床合理用药具有重要意义。本文综述新型抗抑郁药物的药物相互作用,以期为临床用药提供参考。New types of antidepressants are widely used as therapeutic alliance and often in combination with other medications. It may modify the pharmacokinetics mediated by cytochrome P450. The investigation on drug interactions has important significance for rational use of medicine. This paper reviews the drug interactions of the new antidepressants to provide a guideline for combination therapy of antidepressants in clinic.

关 键 词：抗抑郁药物 药物相互作用 选择性5-羟色胺再摄取抑制剂(SSRI) 氟西汀 帕罗西汀 细胞色素P450(CYP450) 

分 类 号：R971.43[医药卫生—药品] R749.4[医药卫生—药学]