黄芪对早产儿免疫功能的影响  

Effect of astragalus on immune function in premature infants

作　　者：张永[1] 王艳丽[1] 刘颖[1] 龙芳[1] 李慈梅[1] 

机构地区：[1]广东省妇幼保健院新生儿科,广州510010

出　　处：《国际医药卫生导报》2012年第13期1848-1851,共4页International Medicine and Health Guidance News

基　　金：广东省中医药局科研基金项目（2010433）

摘　　要：目的探讨黄芪颗粒对早产儿免疫功能的影响。方法将2010年06月至2010年12月在我院住院的符合入选条件的早产儿在入院时随机分为治疗组及对照组，共84例，实际入组共75例；实验组给予黄芪颗粒口服，2g／次，2次／d；对照组给予等量温开水口服；于治疗前、治疗第3、7、14天收集标本，检测血清CD4^＋T细胞比例及CD4^＋／CD8^＋值，IL-2、IFN-γ浓度，粪便分泌型IgA（SIgA）浓度；实验观察时间为14d。结果①两组早产儿血清IL-2、IFN-γ浓度在治疗前、治疗第3天、治疗第7天差异均无统计学意义（P〉0．05）；治疗第14天，治疗组的血清IL-2、IFN-γ浓度[（40．12±9．41）pg／ml、（228．79±45．10）pg／ml]较对照组[（31．53±8．46）pg／ml、（205．16±38．75）pg／m1]明显升高（P〈0．05）。②两组早产儿粪便SIgA浓度在治疗前及治疗第3天差异无统计学意义（P〉0．05）；治疗第7天及第14天，治疗组早产儿便SIgA浓度[（1．96±0．58）、（2．65±0．60）μmol／L]均高于对照组f（1．48±0．51）、（1．89±0．62）μmol／L1，差异具有统计学意义（P〈0．05）。③两组早产儿血清中CD4^＋T细胞比例及CD4^＋／CD8^＋值在治疗前、治疗第3天及第7天差异均无统计学意义（P〉0．05），而在治疗第14天CD4^＋T细胞比例及CD4^＋／CD8^＋值水平较治疗前均增高，并且在治疗第14天，治疗组CD4^＋T细胞[（61．76±6．33）％]及CD4^＋／CD8^＋值[（3．52±0．69）％]比对照组[（56．34±8．46）％、（3．02±0．74）％]明显增高，差异有统计学意义（P〈0．05）。结论黄芪服用一定时间后对早产儿的细胞免疫及体液免疫功能有增强作用。Objective To investigate the effect of astragalus on immune function in premature infants. Methods Eighty four preterm infants who had been hospitalized from June to December 2010 and who met the inclusion criteria were randomly divided into treatment group （ n=-37 ） and control group （ n=-38 ）, 9 of whom withdrew from the study. The treatment group received oral astragalus particles of 2 g twice daily, while the control group received the same amount of warm water. Blood specimens were collected before treatment and on days 3, 7, and 14 to detect CD4^＋ count, CD4^＋/CD8^＋ , serum levels of IL-2 and IFN-γ, and so was SIgA level in feces. Results Before treatment and on days 3 and 7, serum levels IL-2 and IFN-γ did not differ sigificantly between the two groups. However, with the progress of experiment, levels of IL-2 and IFN-γ in the treatment group[（ 40.12 ± 9.41 ）, （ 228.79 ± 45.10 ）pg/ml] were significantly higher than that in the control group [（ 31.53 ± 8.46 ）, （ 205.16 ± 38.75 ） pg/ml, （ P〈 0.05 ）]. The fecal SIgA level did not differ significantly between the two groups before treatment and on day 3 （ P〉 0.05 ） and was significantly higher in the treatment group[（ 1.96 ±0.58 ）, （ 2.65 ±0.60 ） μ mol/L] than in the control group [（ 1.48± 0.51 ）, （ 1.89 ± 0.62 ） μ mol/L on days 7 and 14 （ P 〈 0.05 ）. The CD4^＋ T cell percentage and CD4^＋ / CD8^＋ ratio did not differstatistically before treatment and on days 3 and 7 and were not increased until day lg, the CD4^＋ T cell percentage and CD4^＋ / CD8^＋ ratio in the treatment group （ 61.76 ± 6.33, 3.52 ±0.69 ）were significantly higher than that in the control group （ 56.34 ±8.46, 3.02± 0.74, P〈 0.05 ）. Conclusions Astragalus has a positive effect on immune function in premature infants.

关 键 词：黄芪 早产儿 免疫功能 

分 类 号：R272[医药卫生—中医儿科学]