重度血小板减少对妊娠合并狼疮患者的影响  

Effect of severe lupus-associated thrombocytopenia on pregnant women with systemic lupus erythe- matosus

作　　者：张建瑜[1] 屈谦[1] 唐加明[1] 罗冰[1] 黄凯清[2] 

机构地区：[1]广州医学院第三附属医院血液风湿科,510150 [2]广州医学院第三附属医院妇产科,510150

出　　处：《国际医药卫生导报》2012年第13期1938-1940,共3页International Medicine and Health Guidance News

摘　　要：目的探讨重度血小板减少症（sever thrombocytopenia，STP）对狼疮合并妊娠患者妊娠结局、产科并发症影响。方法对2006至2011年收治的11例妊娠合并SLE性STP患者临床资料进行回顾性分析。结果49例妊娠合并狼疮患者中，重度血小板减少（血小板低于40×10^9／L）11例（中位数为28×10^9／L，范围为5．38×10^9／LoSTP主要发生在妊娠晚期，常常合并多脏器损害。该组病例中4例胎儿丢失（包括治疗性引产3例、治疗性流产1例），余7例活产，其中早产儿5例，低体重儿4例，新生儿体重中位数为2212g。结论SLE相关的STP患者全身系统性病变严重，经过及时处理，在严密的围产期监测下，注意防治妊娠并发症，可获得较好的妊娠结局。Objective To investigate the effect of severe thrombocytopenia （ STP ） on pregnancy outcomes and obstetric complications in pregnant women with systemic lupus erythematosus （ SLE ）. Methods The clinical data on 11 pregnant women with SLE-associated STP who had treated during the period of 2006 to 2011 were analyzed retrospectively. Results 11 of 49 pregnant women with SLE met the criteria for platelet count of less than 40× 10^9/L, with a median count of 21× 10^9/L, ranging from 5 to 38×10^9/L. STP mainly occurred in the third trimester, which was always complicated with multiple organ damage. Cesarean sections were performed in all patients. Fetal loss occurred in 4 women, premature labor in 5, and low neonatal weight in 4. The median neonatal weight was 2212 g. Conclusions Even though the systemic symptoms were severe, the women with thrombocytopenia induced by lupus have a better pregnancy outcome under the conditions of proper treatment and close supervision during the perinatal period.

关 键 词：红斑狼疮 血小板减少 妊娠结局 

分 类 号：R714.25[医药卫生—妇产科学]