宁夏地区囊型包虫病患者HLA-DRB1基因与易感相关性研究  

Association of HLA-DRB1 allele and the susceptibility to cystic echinococcosis in Ningxia

作　　者：马学平 秦迎旭 高建炜 路宗仁[2] 王志平 李丽 

机构地区：[1]宁夏自治区疾病预防控制中心人畜共患病实验室,宁夏银川750004 [2]宁夏西吉县疾病预防控制中心,宁夏西吉756200 [3]宁夏海原县疾病预防控制中心,宁夏海原755200

出　　处：《宁夏医学杂志》2012年第7期605-607,I0001,共4页Ningxia Medical Journal

基　　金：宁夏自然科学基金资助项目(NZ09188)

摘　　要：目的了解人类白细胞抗原HLA-DRB1等位基因与宁夏囊性包虫病易感相关性,为探寻包虫病的易感基因或抗病基因提供线索。方法采用微量聚合酶链反应-序列特异性引物技术(PCR-SSP)对63例囊性包虫病患者和45例正常人群进行HLA-DRB1等位基因多态性检测。结果 HLA-DRB1基因的等位基因DRB1*03和DRB1*09基因型在病例组中的分布频率显著高于对照组,差异有统计学意义(P<0.05);其它等位基因的基因型在病例组和对照组中的分布差异无统计学意义(P>0.05),其中DRB1*14和DRB1*17基因型在病例组和对照组中均未检出。结论 HLA-DRB1*03和DRB1*09基因可能与囊型包虫病易感具有相关性。Objective To understand HLA - DRB1 allele and the susceptibility to cystic echinococcosis in Ningxia. Methods A total of 63 cystic echinococcosis and 45 healthy controls were selected and analyzed by using polymerase chain reaction with sequence - specific primers （ PCR - SSP） to test their HLA - DRB1 allele gene polymorphism. Results Compared with normal controls, frequency of HLA - DRB1 ＊ 03 and HLA - DRB1 ＊ 09 were significantly increased in patients （ P 〈 0.05 ）. There were no differences in the distributions of other allele genotypes between case group and control group （P 〈 0.05）, and HLA -DRB1 ＊ 14 and HLA - DRB1 ＊ 17 genotypes was not detected in case group and control group. Conclusion HLA - DRB1 ＊ 03 and DRB1 ＊ 09 geno- types maybe relate to the susceptibility of cystic echinococcosis.

关 键 词：囊型包虫病 HLA-DRB1基因 易感相关性 

分 类 号：R532.32[医药卫生—内科学]