(1S,2S)-1,2-二苯基乙二胺修饰Ir/SiO_2催化苯乙酮及其衍生物不对称加氢(英文)  

(1S,2S)-Diphenylethylenediamine Modified Ir/SiO_2 Catalyst for Asymmetric Hydrogenation of Acetophenone and Its Derivatives

作　　者：杨朝芬[1] 杨俊[1] 孙晓东[1] 朱艳琴[1] 王齐[1] 陈华[2] 

机构地区：[1]昆明理工大学分析测试研究中心,云南昆明650093 [2]四川大学化学学院有机金属络合催化研究所,绿色化学与技术教育部重点实验室,四川成都610064

出　　处：《催化学报》2012年第7期1154-1160,共7页

摘　　要：不添加任何稳定剂,在碱性条件下制备了5%Ir/SiO2催化剂,并用于催化苯乙酮的不对称加氢反应中,详细考察了碱和手性修饰剂种类、氢气压力、反应温度、(1S,2S)-1,2-二苯基乙二胺((1S,2S)-DPEN)浓度对反应的影响.在优化反应条件下,5%Ir/SiO2催化剂表现出较好的反应活性和对映选择性.其中,苯乙酮不对称加氢反应的对映选择性达70%.该催化剂不需要任何稳定剂,制备方法简单,催化性能稳定,通过简单的离心分离即可循环使用.An efficient and highly dispersed 5%Ir/SiO2 catalyst for the asymmetric hydrogenation of acetophenone and its derivatives were prepared under basic conditions without the use of any stabilizer. The effects of different reaction parameters, namely, catalyst preparation, base used, chiral modifier, and concentration of （1S,2S）-diphenylethylenediamine （（1S,2S）-DPEN）, were evaluated. Under optimum conditions with 5%Ir/SiO2 modified by （1S,2S）-DPEN, a high ee value of 70.0% was obtained for the asymmetric hydrogenation of acetophenone. It is noteworthy that this highest ee value was obtained with a supported metal catalyst without any stabilizer. The catalyst preparation is simple and there was no loss of enantioselectivity when the catalyst was reused several times.

关 键 词：铱 苯乙酮 多相不对称加氢 (1S 2S)-1 2-二苯基乙二胺 对映选择性 

分 类 号：O643.32[理学—物理化学]