老年脑卒中抑郁患者血清同型半胱氨酸水平观察  

Relationship between Serum Homocysteine and Post-stroke Depression in Elderly

作　　者：涂文军[1,2] 陈惠[1,2] 史晓东[1,2] 赵圣杰[3] 

机构地区：[1]首都医科大学康复医学院,北京市100068 [2]中国康复研究中心北京博爱医院,北京市100068 [3]上海交通大学附属第一人民医院,上海市200080

出　　处：《中国康复理论与实践》2012年第7期645-646,共2页Chinese Journal of Rehabilitation Theory and Practice

摘　　要：目的讨论老年脑卒中后抑郁患者血清同型半胱氨酸水平与抑郁的关系。方法 62例脑卒中后抑郁老年患者以及20例脑卒中后无抑郁老年患者采用荧光偏振免疫分析(FPIA)检测同型半胱氨酸。100例老年健康体检者作为对照组。结果卒中后抑郁组、卒中后非抑郁组、对照组血清同型半胱氨酸水平分别为(25.59±9.47)μmol/L、(18.56±7.84)μmol/L、(12.67±6.45)μmol/L,两两比较均存在显著性差异(P<0.05)。在卒中后抑郁组,血清同型半胱氨酸水平与汉密尔顿抑郁量表评分(r=0.8953,P<0.05)、年龄(r=0.8462,P<0.05)均相关。结论脑卒中后血清同型半胱氨酸水平与抑郁发病相关。Objective To investigate the relationship between serum homocysteine and post-stroke depression in elderly. Methods 62 elderly first stroke patients with post-stroke depression, 20 first stroke patients without depression, and 100 healthy elderly as control were de- tected their fasting serum homocysteine with fluorescence polarization immunoassay. Results Serum homocysteine were （25.59±9.47） μmol/ L, （18.56±7.84） μmol/L, and （12.67±6.45） μmol/L in the depression group, non depression group and healthy group, respectively （P〈0.05）. The level of homocysteine correlated with the score of Hamilton Depression Scale （r=0.8953, P〈0.05） and age （r=0.8462, P〈0.05）. Conclusion The level of serum homocyteine might be one of risk factor of depression in patients with stroke.

关 键 词：卒中后抑郁 老年 同型半胱氨酸 

分 类 号：R714.246[医药卫生—妇产科学]