环孢素A与甲氨蝶呤治疗难治性泛发性脓疱型银屑病疗效比较  

Efficacy comparison between CysA and MTX in treatment of refractory generalized pustular psoriasis

作　　者：李尚坤[1] 黄克[1] 吴海娟[1] 

机构地区：[1]广东省惠州市皮肤病医院,516008

出　　处：《临床合理用药杂志》2012年第20期23-24,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的探讨环孢素A与甲氨蝶呤(MTX)治疗难治性泛发性脓疱型银屑病(GPP)的临床疗效。方法将48例难治性GPP随机分为A组和B组各24例。A组采用环孢素A治疗,B组采用MTX治疗。比较2组的临床疗效、症状和体征消失时间、复发率及不良反应。结果 A组总有效率和复发率分别为87.5%、8.3%,B组为79.2%、12.5%,2组比较差异均无统计学意义(P>0.05)。A组体温恢复正常时间及红斑、脓疱消退时间短于B组;血压升高发生率高于B组,肝功能、血常规异常发生率低于B组,差异均有统计学意义(P<0.05和P<0.01)。但2组肾功能、尿常规异常发生率比较差异无统计学意义(P>0.05)。结论环孢素A与MTX治疗难治性GPP均能取得较好的临床疗效,且环孢素A具有起效更快、对肝功能影响较小等优点。Objective To discuss the clinical efficacy of CysA and MTX in treatment of refractory generalized pustular psoriasis.Methods 48 cases with refractory generalized pustular psoriasis were randomly divided into A group and B group,each of 24 cases.A group was treated with CysA,and B group was with MTX.The clinical efficacy,the average times for symptoms and signs to disappear,relapse rate and untoward reaction was compared between 2 groups.Results The total effective rate and recurrence rate of A group were 87.5%,8.3%,which of B group were 79.2%,12.5%,there were no significant difference between 2 groups（P〉0.05）.The recovery time of temperature and the recession time of erythema and pustule of A group were shorter than that of B group;hypertension cases of A group were more than B group;and abnormal routine blood cases and dysfunction of liver of A group were less than that of B group,the differences were statistically significant（P0.05）.Conclusion CysA and MTX in treatment of refractory generalized pustular psoriasis show good clinical efficacy.And CysA takes effects faster,with little effect on liver and renal function.

关 键 词：环孢素A 甲氨蝶呤 泛发性脓疱型银屑病 阿维A 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]