磷酸川芎嗪的体外透皮吸收  

Transdermal Absorption of Ligustrazine Phosphate in vitro

作　　者：王晖[1] 高莉莉[2] 许卫铭[1] 刘刚[1] 

机构地区：[1]广东医学院药理学教研室,湛江524023 [2]广东医学院中心实验室,湛江524023

出　　处：《中草药》2000年第2期117-119,共3页Chinese Traditional and Herbal Drugs

摘　　要：对磷酸川芎嗪透皮吸收的规律及释药机制进行探讨。采用离体透皮实验装置 ,通过改变药物浓度、p H值、促透剂及皮肤状态 ,研究磷酸川芎嗪的透皮吸收。结果发现随着磷酸川芎嗪浓度增加 ,渗透系数明显增加 ;p H增大 ,渗透系数随之增加 ;氮酮在 1%时可显著增加磷酸川芎嗪的透皮吸收 ;当去除角质层后 ,渗透系数比完整皮肤增加近一半 ;完整皮肤的贮库效应大于去角质层皮肤。提示磷酸川芎嗪可透皮吸收 ,吸收的主要屏障是角质层 。Factors influencing the transdermal penetration of ligustrazine phosphate (LP) through rabbit skin were studied in vitro. Results showed that the permeation coefficient was increased when the concentration of LP and pH increased; 1 percent azone could significantly enhanced LP transdermal absorption; the permeation coefficient of stripped stratum corneum skin was higher than that of whole skin; and the deposit function of whole skin was larger than that of stripped stratum corneum skin. It was concluded that LP could be absorbed through skin, the main barrier of absorption was the stratum corneum, and LP had the deposit function also in the stratum corneum.

关 键 词：磷酸川芎嗪 透皮吸收 贮库效应 渗透系数 中药 

分 类 号：R286.2[医药卫生—中药学]