氟尿嘧啶炭纳米粒制剂在大鼠血液和淋巴中药物浓度比较  

Comparion of drug concentration of fluorouracil carbon nanoparticles formulation in rat blood and lymph

作　　者：冀强[1] 李书莲[2] 张丹[3] 

机构地区：[1]成都大学附属医院,成都市610081 [2]四川大学华西医院甲乳科,成都市610041 [3]四川大学华西药学院,成都市610041

出　　处：《临床合理用药杂志》2012年第22期71-72,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的对氟尿嘧啶(5-Fu)炭纳米粒新型制剂在大鼠体内血液和淋巴中进行药物动力学研究。方法采用反效液相色谱法(RP-HPLC)测定大鼠腹腔注射5-Fu炭纳米粒新剂型与普通剂型(20mg/kg体质量)后在两者体内的血药浓度和淋巴浓度,并对两者代谢时间进行比较。结果 (1)相同时间内,不论是血液中还是淋巴组织中,炭纳米粒新型制血药峰浓度显著大于普通剂型;(2)15min内,血液和淋巴组织中药物浓度比较接近,而30min后淋巴组织中药物浓度明显高于血液中药物浓度,且淋巴组织内药物释放时间更长。结论腹腔内注射5-Fu炭纳米粒,在淋巴组织中能较血液长时间内维持相对较高的药物浓度。Objective To study the pharmacokinetic of fluorouracil （5-Fu） carbon nanoparticles formulation in rat blood and lymph. Methods Reversed phase-high performance liquid chromatography （RP-HPLC） was used to estimate the lymphoid and blood tissue concentration after caudal vein 5-Fu carbon nanoparticles formulations and ordinary formulation （20 mg/kg body weight）. Results At the same time,in blood or lymphatic tissue,drug concentrations of （5-Fu） carbon nanopar- tides formulation were higher than those of 5-Fu ordinary injection. The drug concentration in blood closed to the lymphoid tis- sues withinl5 min, after 30min, lymphatic 5-Fu concentration were higher than the blood, and lymphoid tissues of drug released a longer time. Conclusion Intraperitoneal injection of 5-Fu carbon nanoparticles maintain a relatively higher concentration of the drug in lymphoid tissue than blood for a long time.

关 键 词：氟尿嘧啶 药物动力学 大鼠 炭纳米粒 

分 类 号：R965[医药卫生—药理学]