消瘀片分煎剂、合煎剂及单组分对高脂血症小鼠调脂作用的比较  

Comparison of Blood lipid Regulating Action of Separate and Mixed Decoction of Xiao yu Tablets and Its Single Constituents on Hyperlipidemic Mice

作　　者：陆群[1] 朱路佳[1] 谢梅林[1] 顾振纶[1] 

机构地区：[1]苏州中药研究所,江苏苏州215007

出　　处：《中成药》2000年第2期153-155,共3页Chinese Traditional Patent Medicine

摘　　要：目的 :探讨丹参和山楂提取工艺及组方的合理性。方法 :采用高脂血症小鼠模型 ,观察消瘀片分煎剂、合煎剂及单组分对血脂的影响。结果 :消瘀片分煎剂对降低高脂血症小鼠TC、TG、LDL C和apoB含量 ,增加HDL C、apoAI及apoAI/apoB比值的作用 ,均较消瘀片合煎剂及单组分要强。 结论 :丹参水提取物和山楂醇提取物组成的消瘀片对调节小鼠血脂水平具有更强的作用。Objective:To determine the rationalities of extraction method and prescription of Radix Salviae Miltiorrhizae (SM) and Fructus Crataegi (FC).Methods:The effects of separate and mixed decontion of Xiaoyu Tablets and its single constituents on the blood lipid of hyperlipidemic mice were observed.Results:The separate deconction of Xiaoyu Tablets showed stronger actions than the mixed decoction and single constituents in decrearing the contents of TC, TG, LDL C and apolipoprotein (apo B) of hyperlipidemic mice, increasing the levels of high density lipoprotein cholesterol and apolipoprotein AI(apoAI) and the ratio of apoAI/apoB. Conclusion:Xiaoyu Tablets, composed of water extract of SM and ethanol extract of FC, has stronger blood lipid regulating action.

关 键 词：消瘀片 高脂血症 调脂作用 小鼠 中医药疗法 

分 类 号：R259.892[医药卫生—中西医结合] R285.5[医药卫生—中医内科学]