朱砂中汞的生物可接受性及其吸收与排泄  

Bioaccessibility as well as absorption and excretion of mercury in cinnabar

作　　者：霍韬光[1] 王海宇[2] 林欣然[3] 畅蓓[1] 李维凯[1] 杨卉蕾[1] 张颖花[1] 姜泓[1] 

机构地区：[1]中国医科大学公共卫生学院,辽宁沈阳110001 [2]中国医科大学预防医学院,辽宁沈阳110001 [3]中国医科大学临床医药学院,辽宁沈阳110001

出　　处：《化学研究》2012年第4期52-55,59,共5页Chemical Research

基　　金：国家自然科学基金资助项目(81073144)

摘　　要：研究了朱砂中汞的生物可接受性及其在体内的吸收与排泄.采用体外消化透析法测定了朱砂中汞的生物可接受性;计算了大鼠灌胃给予临床剂量(50mg/kg)朱砂后汞的药动学参数;测定了给予临床剂量的朱砂后大鼠粪样中汞的排泄量.结果表明,朱砂中汞的溶出率为0.011%,生物可接受率为0.003 3%.大鼠灌胃给予临床剂量的朱砂后,汞的药动学参数为:最高血药浓度(ρmax)为(6.3±1.3)μg/L,达峰时间(tmax)为(1.3±0.4)h,半衰期(t1/2)为(4.2±0.5)h,血药浓度-时间曲线下面积(AUC)为(54.7±8.7)μg.h.L-1.给予朱砂12h后汞在粪便中排泄量最大,96h后在粪样中仍可检测到少量汞.朱砂中汞的生物可接受性较低,在体内吸收少,滞留时间较长,排泄缓慢,长期服用可在体内蓄积,产生毒性.The bioaccessibility and absorption and excretion of mercury in cinnabar were studied.The bioaccessibility of mercury in cinnabar was evaluated by adopting in vitro digestion and dialysis method to simulate the conditions of gastric compartment and intestinal compartment of mercury.The pharmacokinetic parameters of mercury with respect to intragastric administration of cinnabar at a clinical dosage of 50 mg/kg for rats were calculated;and the excretion fraction of mercury in the fecal sample of the rats after intragastric administration of cinnabar at a clinical dosage was determined.Results indicate that,in the gastric compartment,the solubility of mercury from cinnabar is 0.011%;and the bioaccessibility of mercury in the intestinal compartment is 0.003 3%.The time-course pharmacokinetic parameters of mercury when the rats are intragastrically given cinnabar at a clinical dosage of 50 mg/kg are determined as the maximum concentration in blood Cmax（6.3±1.3） μg/L,time to reach the maximum concentration tmax（1.3±0.4） h,half-time period t1/2（4.2±0.5） h,and area under the concentration-time curve AUC（54.7±8.7） μg·h/L.A large quantity of mercury was found in the feces of the rats which were given cinnabar 12 h ago,and a small amount of mercury was still detected in the feces of the rats even after they were given cinnabar 96 h ago.In one word,the bioaccessibility of mercury in cinnabar is low.A small amount of mercury can be absorbed by body.However,it takes a long time to eliminate the absorbed mercury,and the excretion rate is slow.Thus long time use of cinnabar may cause toxicity owing to mercury accumulation.

关 键 词：朱砂 汞 生物可接受性 吸收与排泄 

分 类 号：O614.24[理学—无机化学]