托特罗定联合盆底电刺激治疗女性膀胱过度活动症效果观察  

Clinical effects of tolterodine with pelvic floor electrical stimulation in the treatment of female OAB patients

作　　者：刘宁[1] 刘春林[1] 冯超[1] 张进生[1] 渠渊[1] 

机构地区：[1]首都医科大学附属复兴医院泌尿外科,北京100038

出　　处：《中国综合临床》2012年第8期867-869,共3页Clinical Medicine of China

摘　　要：目的观察托特罗定联合盆底神经电刺激治疗女性膀胱过度活动症的效果并探讨其作用机制。方法将2009年10月至2010年12月就诊的73例女性膀胱过度活动症患者随机分为两组：托特罗定组口服托特罗定2mg／次，2次／d，疗程4周；联合治疗组口服托特罗定2mg／次，20：／d，加用盆底神经电刺激治疗，隔日1次，疗程4周。结果与治疗前比较，两组患者的膀胱过度活动症状（尿急、急迫性尿失禁、排尿次数、每次排尿量）减轻（P均〈0．05）。两组之间比较，在减轻尿急次数、尿失禁次数及夜尿次数指标上，两组差异无统计学意义（P均〉0．05），但联合治疗组在减少每日排尿次数[（5．6±0．1）次]及每次排尿量[（248±14．6）ml]的增加方面优于托特罗定组[（7．6±0．3）次、（207±11．3）ml]，差异有统计学意义（P均〈0．05）。结论托特罗定联合盆底神经电刺激能明显改善女性OAB症状，提高患者生活质量，疗效优于单用托特罗定，有一定临床意义。Objective To investigate whether tolterodine combined with pelvic floor electrical stimulation is more effective than tolterodine alone in the treatment of women with overactive bladder（OAB） and the underlying mechanism. Methods Seventy-three female patients with OAB were recruited from our hospital during Oct. 2009 to Dec. 2010 and prospectively studied,of whom 39 cases were given tolterodine（2 mg each time, twice daily for g weeks）alone while the other 34 cases were given tolterodine combined with pelvic floor electrical stimulation for the treatment of OAB. Data on urgency, incontinence, micturition frequency, nocturia episodes and voided volume were collected before and after 4 weeks＇ treatment using a week micturition diary, Results The differences of changes of OAB symptoms between the 2 groups had statistical significance （ P 〈 0. 05 ）. Patients in the tolterodine combined with pelvic floor electrical stimulation group reported treatment benefit than the toherodine group in the micturitions and the volume voided per micturition （P 〈 0. 05 ）. There were no difference in the number of urgency episodes per 24 hours, incontinence episodes and nocturnal episodes （P 〉 0. 05 ）. Conclusion A combination of toterodine with pelvic floor electrical stimulation could significantly improve the OAB symptoms, and is a potential therapy for female patients with OAB.

关 键 词：托特罗定 盆底电刺激 女性膀胱过度活动症 

分 类 号：R694[医药卫生—泌尿科学]