散发型克—雅病的临床特点探讨  

Characteristics of Suspected Sporadic Creutzfeldt-Jakob Disease

作　　者：母艳蕾[1] 彭丹涛[1] 

机构地区：[1]卫生部北京医院神经内科,北京100730

出　　处：《临床药物治疗杂志》2012年第4期9-12,共4页Clinical Medication Journal

基　　金：国家自然科学基金(30971000);首都医学发展科研基金(2007-3011)

摘　　要：目的:探讨散发型克-雅病(Sporadic Creutzfeldt-Jakob Disease,sCJD)的临床特点。方法:总结3例疑诊为sCJD病例的临床特点,并复习相关文献。结果:3例患者均表现为快速进展的认知功能的减退,脑电图和影像学、脑脊液有异常表现。结论:克-雅病是最常见的人类朊蛋白病,临床诊断主要依靠临床表现、EEG和CSF检查相结合,MRI序列如弥散加权成像(diffusion weighted imaging,DWI)液体衰减翻转恢复成像有助于早期疾病的临床诊断。对3例患者临床特点的总结有助于今后的临床工作中对sCJD做出更加准确和及时的诊断。Objective： To characterize clinical features of 3 suspeated sCJD. Methods： we analyzed the clinical features of 3 suspected sCJD retrospectively, and reviewed related literature. Results： All of the A rapidly progressive dementia developed in 3 suspected patients,and abnormal outcomes of MRI, EEG and CSF studies findings were observed.Conclusion： Creutzfeldt- Jakob Disease is the most prevalent human pdon disease, the clinical diagnosis can be made accordig to the clinical signs, symptoms, EEG and CSF examinations.MR sequences such as diffusion weighted imaging（DWI） and fluid-attenuated inversion recovery imaging （FLAIR） are useful for the early clinical diagnosis. Characteristics of.these 3 patients are provided to facilitate further clinical investigation that may lead to more reliable and timely diagnoses of sCJD.

关 键 词：克-雅病 核磁共振 脑脊液 脑电图 诊断 治疗 

分 类 号：R563.1[医药卫生—呼吸系统] R977.1[医药卫生—内科学]