Cramp基因对小鼠脾脏及胸腺细胞发育的影响  

Influence of Cramp Knockout on Cell Development of Spleen and Thymus in Mice

作　　者：石桂英[1] 白琳[1] 鞠振宇[1] 

机构地区：[1]中国医学科学院北京协和医学院实验动物研究所卫生部人类疾病比较医学重点实验室国家中医药管理局人类疾病动物模型三级实验室,北京100021

出　　处：《环境与健康杂志》2012年第7期601-603,共3页Journal of Environment and Health

基　　金：中央级公益性科研院所基本科研业务经费资助项目(DWS201010)

摘　　要：目的研究Cramp基因敲除在衰老过程中对小鼠脾脏及胸腺细胞发育及组成的影响。方法应用流式细胞仪分析不同年龄Cramp基因敲除C57BL/6J小鼠及同龄野生型小鼠的脾脏、胸腺等组织器官中各种细胞的比例。结果与野生型小鼠相比,Cramp基因敲除小鼠的脾脏、胸腺等组织器官中各种细胞的比例均无明显变化。结论本研究中,Cramp基因敲除对不同年龄小鼠脾脏及胸腺等组织器官的细胞发育无明显影响。Objective To study the influence of Cramp gene on the development of mice spleen and thymus cells in aging. Methods The cells collected from the spleen and thymus of different age Cramp knockout and wild type mice were analyzed by flow cytometry. Results Compared with wild type mice, there were no significant differences in the cell percentage of spleen and thymus in Cramp knockout mice. Conclusion Compared with the wild type mice, there is no significant difference in the development of spleen and thymus cells in different ages Cramp knockout mice.

关 键 词：Cramp基因敲除小鼠 流式细胞术 脾脏 胸腺 

分 类 号：R994.6[医药卫生—毒理学]