二甲基乙酰胺职业接触及与尿中甲基乙酰胺的关系  

Correlation between Urinary N-methylacetamide and Occupational Exposure to N,N-dimethylacetamide

作　　者：钱亚玲[1] 徐承敏[1] 路艳艳[1] 吴昊[1] 唐红芳[1] 蒋兆强[1] 柴剑荣[1] 张幸[1] 

机构地区：[1]浙江省医学科学院卫生学研究所,浙江杭州310013

出　　处：《环境与职业医学》2012年第7期434-436,440,共4页Journal of Environmental and Occupational Medicine

基　　金：浙江省公共卫生检验检测重点学科群建设项目(编号:XKQ-009-003);职业危害检测关键技术研究和应用实验室项目(编号:2011F10049)

摘　　要：[目的]探讨职业二甲基乙酰胺(DMAC)接触与尿中甲基乙酰胺(NMAC)的相关性。[方法]对3家氨纶生产企业6个工种201名工人进行空气中DMAC暴露浓度监测及工作周末班末尿样采集,同时对20名纺丝工连续一周空气样品和班末尿样的采集;分别用气相色谱测定空气中DMAC和尿中NMAC含量。[结果]氨纶生产过程中组件清洗工、纺丝工接触DMAC水平最高(P<0.0033),中位数分别为32.10、22.02mg/m3,其尿中NMAC浓度较其他工种高(P<0.0033),中位数分别为30.09、22.72mg/gCr;工作周末班末尿NMAC含量与空气中DMAC浓度呈直线相关,直线方程为log(U-NMAC)=0.685+0.455×log(A-DMAC)(r=0.698,P=0.001);长期DMAC接触者,接触2d后尿中NMAC呈较高水平(P<0.0033);个体DMAC接触代谢转化为NMAC的相对内暴露指数(RIE)与DMAC接触浓度呈负相关(rs=-0.781,P=0.001)。[结论]工作周末班末尿NMAC含量与空气中DMAC浓度呈良好对数线性关系。[ Objective ] To examine the correlation between occupational N, N-dimethylacetamide （DMAC） exposures and urinary N-methylacetamide （NMAC）. [ Methods ] A total of 201 workers of 6 work types exposed to DMAC in 3 spandex factories were recruited. Air samples were collected from each work type site, post-shift urine samples at the end of workweek were collected from all studied workers and also from 20 spinning workers at each end of workday for 5 consecutive days. NMAC in urine and DMAC in air were determined by gas chromatography. [ Results ] The time-weighted average （TW.A） air levels of DMAC were highest in module washing and spinning sites （P 〈 0.003 3＂）, medians being 32.10 and 22.02 mg/m3 respectively. The urinary NMAC concentrations in module washing workers and spinning workers were significantly higher than workers of other Work types, medians being 30.09 and 22.72mg/gCr respectively. A linear Correlation was found between the TWA air levels of DMAC and the creatinine- adjusted NMAC levels in urine collected by the end of workweek （r=0.698, P = 0.001）. The linear equation was log（U-NMAC）= 0.685＋0.455 × log（A-DMAC）. After 2 consecutive days of exposure, the urinary NMAC was at a higher level in chronically exposed workers （P〈0.003 3）. A negative linear correlation was found between the DMAC levels in air and the relative internal exposure （RIE） （r,=-0.781, P = 0.001）. [ Conclusion ] Air DMAC contents are significantly correlated with urinary NMAC concentrations after logarithmic transformation.

关 键 词：二甲基乙酰胺 生物监测 甲基乙酰胺 尿 

分 类 号：R134.4[医药卫生—劳动卫生]