衍生-顶空气相色谱法测定化妆品中游离甲醛  

Determination of Dissociate Formaldehyde in Cosmetics by Derivatization-Headspace-Gas Chromatography

作　　者：王斌[1] 李金花[1] 汪国权[1] 

机构地区：[1]上海市疾病预防控制中心卫生检测室,上海200336

出　　处：《环境与职业医学》2012年第7期459-461,共3页Journal of Environmental and Occupational Medicine

摘　　要：[目的]以五氟苯肼(PFPH)衍生化,建立简单、高效的化妆品中游离甲醛的衍生-顶空气相色谱测定方法,以满足实验室日常检测的需要。[方法]采用水进行液-液提取,用PFPH进行衍生,顶空气相色谱进行分离,氢火焰离子化检测器进行检测。[结果]通过衍生能有效去除干扰,该方法加标浓度在8.0～40.0mg/kg范围内,平均回收率为106%,精密度范围为1.8%～5.2%(n=6)。方法检出限为0.6mg/kg。[结论]本方法测定化妆品中游离甲醛,快速、简单、可靠,可满足实验室日常检测需要。[ Objective ] To establish a simple and efficient method for determination of dissociate formaldehyde in cosmetics samples by derivatization-headspace-gas chromatography, and to meet requirements of daily inspections. [ Methods ] Dissociate formaldehydes were extracted by liquid-liquid extraction technique using water and derivatized with pentafluorop henylhydrazine （PFPH）. The derivatives were separated by gas chromatography and measured by hydrogen flame ionization detector. [ Results ] The derivatization reaction effectively removed interferences. The spiked concentrations of this method were 8.0-40.0 mg/kg. The average recovery was 106% and the relative standard deviation （RSD） ranged from 1.8% to 5.2% （n=6）. The detection limit was 0.6mg/kg. [ Conclusion ] This method for dissociate formaldehyde determination in cosmetics is simple, quick and accurate. It can meet routine laboratory testing requirements.

关 键 词：甲醛 化妆品 衍生 气相色谱 

分 类 号：R115[医药卫生—公共卫生与预防医学]