水模型鉴定PET-CT同机融合图像配准误差  

Registered error between PET and CT images confirmed by a water model

作　　者：陈仰纯[1,2] 张春粦[3] 徐浩[1] 陈萍[2] 樊明武[1,3] 

机构地区：[1]暨南大学附属第一医院核医学科,广州510632 [2]广州医学院第一附属医院PET-CT中心,广州510230 [3]暨南大学理工学院,广州510632

出　　处：《核技术》2012年第8期619-623,共5页Nuclear Techniques

基　　金：国家自然科学基金项目(30800274)资助

摘　　要：本文是应用水模型模拟PET-CT实际检查检测同机融合图像的配准误差。首先制备含59.2 MBq[氟18]-氟代脱氧葡萄糖的水模型,静置80 min,采集2D PET图像20 min,然后经形态学处理与阈值法得水的CT与PET图像,把两组图像的质心位置经线性回归方程拟合,求配准误差。并用Alignment软件测量CT与PET成像系统配准误差4次。得出水PET图像质心较CT图像在X轴偏移(0.011×层数+0.63)mm;在Y轴质心偏移(0.022×层数+1.35)mm,PET图像须经平移且X轴须旋转(0.06±0.07)、Y轴旋转(0.01±0.08)才能与CT图像配准。所以检查床的负载与分布不影响本PET/CT仪系统的配准校正,测量坐标轴旋转角度的随机误差易使PET与CT配准产生偏差。The registered error between PET and CT imaging system was confirmed by a water model simulatingclinical cases. A barrel of 6750 mL was fiUed with 59.2 MBq [18F]-FDG and scanned after 80 min by 2 dimension model PET/CT. The CT images were used to attenuate the PET images. The CT/PET images were obtained by image morphological processing analyses without barrel wall. The relationship of the water image centroids of CT and PET images was established by linear regression analysis, and the registered error between PET and CT image could be computed one slice by one slice. The alignment program was done 4 times following the protocol given by GE Healthcare. Compared with centroids of water CT images, centroids of PET images were shifted to X-axis （0.011slice＋0.63） mm, to Y-axis （0.022×slice＋1.35） mm. To match CT images, PET images should be translated along X-axis （-2.694-0.15） ram, Y-axis （0.43±0.11） mm, Z-axis （0.86±0.23） mm, and X-axis be rotated by （0.06±0.07）°, Y-axis by （-0.01±0.08）°, and Z-axis by （0.11±0.07）°. So, the systematic registered error was not affected by load and its distribution. By finding the registered error between PET and CT images for coordinate rotation random error, the water model could confirm the registered results of PET-CT system corrected by Alignment oarameters.

关 键 词：正电子计算机体层摄影术 配准误差 随机误差 

分 类 号：R445[医药卫生—影像医学与核医学] R817[医药卫生—诊断学]