高温诱导小鼠胚胎对^(60)COγ射线的适应性反应  

HYPERTHERMIA INDUCED CROSS-ADAPTIVE RESPONSE IN MOUSE EMBRYO TO SUBSEQUENT 60Co γ RAYS EXPOSURE

作　　者：阮明[1] 芦春林[1] 杨业鹏[1] 孙菲[1] 洪敏 杜珩[1] 刘景院[1] 

机构地区：[1]北京医科大学公卫毒理室,北京100083

出　　处：《辐射研究与辐射工艺学报》2000年第3期223-225,共3页Journal of Radiation Research and Radiation Processing

摘　　要：为研究高温复合电离辐射对小鼠早期的胚胎效应，选用以孕 ９ｄ ＬＡＣＡ小鼠，给予 ４２℃ １０ｍｉｎ１．０Ｇｙ ６０Ｃｏ γ射线处理。于孕后第 １８天取出胎鼠，观察生长发育情况，测量脑 ＤＮＡ、 ＲＮＡ、蛋白质含量。结果显示，与对照组相比 １．０Ｇｙ胚鼠组发育迟缓；核酸、蛋白质含量明显下降，而 ４２℃组变化不显著， ４２℃＋１．０Ｇｙ照射组损伤程度介于 ４２℃组与 １．０Ｇｙ组之间。这表明 １．０Ｇｙ ６０Ｃｏ γ线使胎鼠生长发育受到影响。而预先 ４２ ℃ １０ｍｉｎ处理孕鼠；其胎仔对随后较大剂量电离辐 射打击表现出交叉适应性反应。To study the effects of heat and ionizing radiation on mouse embryos, the LACA mice were exposed to 42℃ for 10min and 1.OGy 60Coγ rays on the 9th day after gestation, and development of mouse embryos were observed and the contents of DNA, RNA and protein in the brains of mouse embryos were measured on the 18th day after gestation. Results demonstrated that 1.OGy 60Co γ rays irradiation, compared with control, could induce the development retardation for mouse embryos, and the contents of nucleic acids and protein in brains of mouse embryos irradiated were lwss. Meanwhile 42℃ exposure induce insignificant or less effects. The mouse group with 42℃ treatment followed by 1.OGy 60Co irradiation showed the efffects at the level between the groups with 42℃ and 1.OGy irradiation. Thus, exposure of mouse embryos to 42℃ for 10min prior to irradiation may be could induce their adaptive response to irradiation.

关 键 词：电离辐射 高温 胚胎 核酸 蛋白质 适应性反应 

分 类 号：R811.5[医药卫生—放射医学] Q691.5[医药卫生—临床医学]