工艺条件对壳聚糖和聚乙烯醇共混膜的生物粘附性影响  

Bioadhesion property of blend membrane of chitosan and polyvinyl alcohol

作　　者：李若慧[1] 常康威[2] 张立华[1] 袁志奎[1] 

机构地区：[1]北京联合大学生物化学工程学院,北京100023 [2]北京航空航天大学材料科学与工程学院,北京100191

出　　处：《化工新型材料》2012年第7期131-133,共3页New Chemical Materials

基　　金：科技部国际合作项目(2010DFB30850-3)

摘　　要：壳聚糖和聚乙烯醇溶液经混合,采用相转化法成膜工艺制备壳聚糖和聚乙烯醇共混膜;以猪大肠膜为粘附对象,考察在不同工艺条件下制得共混膜对猪大肠膜的粘附特征。结果表明:当m(CS):m(PVA)=1:4时,共混膜的生物粘附强度最大;在甘油用量较少时,随着甘油的用量增加,粘附强度快速增强,在6%(wt,下同)时达到最大,当超过8%时,粘附强度明显下降后,随着甘油的用量增加,基本保持一个稳定的水平;在成膜温度为70℃时,所形成CS/PVA共混膜的粘附强度最大。扫描电镜照片显示所形成膜的微观形貌呈多孔结构,这种结构对其生物粘附性能会产生重要作用。The chitosan（CS） and polyvinyl alcohol （PVA） blend membranes were prepared in different technical condition via L--S phase inversion. Bioadhesion properties of CS/PVA blend membrane was investigated in vitro through bioadhesion strength with pig intestine The results showed that its bioadhesion strength was maximized when m（CS） ：m（PVA） was 1：4. The bioadhesion strength increased rapidly with increasing of glycerin until the maximum was reached when glycerin added up to 6 %, and then the hioadhesion strength decreased obviously with increasing of glycerin,tended to almost constant when the level of glyc- erin was more than 8%. The bioadhesion strength of CS/PVA blend membranes maximally took value while fomaing membranous was at 70℃. The result of SEM indicated that the membrane surface of the blend system would take shape of porous structure which would effect on bioadhesion properties of CS/PVA blend membranes.

关 键 词：壳聚糖 聚乙烯醇 共混膜 生物粘附性 

分 类 号：R318.08[医药卫生—生物医学工程]