宁夏地区慢性阻塞性肺疾病血清α1-抗胰蛋白酶检测分析  

Analysis of serum levels of α1-antitrypsin of chronic obstructive pulmonary disease in Ningxia

作　　者：邱洁[1] 张雅囡[1] 陈娟[1] 谭海[1] 陆学兰[1] 张锦[1] 

机构地区：[1]宁夏医科大学总医院呼吸内科,宁夏银川750004

出　　处：《中国现代医学杂志》2012年第17期58-61,共4页China Journal of Modern Medicine

基　　金：中华医学会临床医学慢性呼吸道疾病科研专项基金(No:08020600138)

摘　　要：目的结合宁夏地区慢性阻塞性肺疾病(COPD)流行病学调查,探讨该地区α1-抗胰蛋白酶(α1-AT)血清水平以及对COPD发病的影响。方法采用酶联免疫吸附实验法检测267例COPD患者及213例对照组α1-AT血清水平。结果本研究入选的213例对照组中α1-AT平均血清水平为(19.10±7.57)g/L,267例COPD患者中α1-AT平均血清水平为(11.31±4.87)g/L,COPD组α1-AT血清水平显著低于对照组(P=0.000)。对照组中不吸烟组和吸烟组α1-AT值分别为(18.96±7.54)g/L、(18.33±7.66)g/L;COPD组中不吸烟组和吸烟组α1-AT值分别为(11.64±5.52)g/L、(11.02±4.22)g/L,对照组和COPD组两组之间α1-AT血清水平差异无统计学意义。对照组中回、汉族的α1-AT值分别为(20.91±6.97)g/L、(18.71±7.65)g/L;COPD组中回、汉族的α1-AT值分别为(11.03±4.75)g/L、(11.58±4.99)g/L,对照组和COPD组回汉之间的α1-AT血清水平差异无统计学意义。对照组中城镇、乡村的α1-AT值分别为(19.20±7.14)g/L、(18.96±8.21)g/L;COPD组中城镇、乡村的α1-AT值分别为(11.28±4.62)g/L、(11.33±5.14)g/L,对照组和COPD组城镇、乡村间的α1-AT血清水平差异无统计学意义。结论对宁夏地区COPD进行流行病学调查显示,COPD组患者血清α1-AT水平显著低于对照组,α1-AT的降低可能与COPD的发病有关。吸烟、回汉民族间、城乡对α1-AT血清水平无明显影响。【Objective】 To investigate the association between Levels of serum α1-antitrypsin（α1-AT） and COPD with epidemiological survey of chronic obstructive pulmonary disease in Ningxia Hui Autonomous Region.【Methods】 The levels of serum α1-AT in 267 patients with COPD and 213 control subjects were measured by Enzyme Linked Immunosorbent Assay（ELISA）.【Results】 The average levels of serum α1-AT in the control subjects were（19.10±7.57） g/L,whereas,COPD were（11.31±4.87） g/L.There was significant difference between COPD and control group in the levels of serum α1-AT（P =0.000）.In the control subjects,α1-AT values both non-smokers and smokers were（18.96±7.54） g/L and（18.33±7.66） g/L.Likewise,in the COPD group.α1-AT values in non-smokers and smokers were（11.64±5.52） g/L and（11.02±4.22） g/L.There was no significant difference between COPD and control group in α1-AT values of non-smokers and smokers.In the control subjects,α1-AT values among Hui and Han nations were（20.91±6.97） g/L and（18.71±7.65） g/L.Likewise.In the COPD group.α1-AT values in Hui and Han nations were（11.03±4.75） g/L and（11.58±4.99） g/L.There was no significant difference between COPD and control group in α1-AT values of Hui and Han nations.In the control subjects.α1-AT values among cities and villages were（19.20±7.14） g/L and（18.96±8.21） g/L.Likewise.in the COPD group.α1-AT values in cities and villages were（11.28±4.62） g/L and（11.33±5.14） g/L.There was no significant difference between COPD and control group in α1-AT values of cities and villages.【Conclusion】 Ningxia COPD epidemiological survey showed that the levels of serum α1-AT were significantly lower in COPD group compared with control subjects.α1-AT reduction may be a factor of the pathogensis of COPD.Smoking,Hui and Han nations as well as cities and villages on the levels of serum α1-AT were not significantly affected.

关 键 词：肺疾病 阻塞性 Α1-抗胰蛋白酶 血清水平 

分 类 号：R563[医药卫生—呼吸系统]