分散液相微萃取技术在药物分析中的应用  

Application of dispersive liquid-liquid microextraction for determination of pharmaceuticals

作　　者：张婧[1] 马红霞[2] 王岩[1] 

机构地区：[1]广东药学院,广州510006 [2]广州医学院第一附属医院,广州510120

出　　处：《西北药学杂志》2012年第4期375-379,共5页Northwest Pharmaceutical Journal

基　　金：国家自然科学基金(30701119);广东省自然科学基金(9151008901000050);广东省科技计划项目(201197);中山市科技计划项目(2009H019)

摘　　要：目的综述分散液相微萃取(dispersive liquid-liquid microextraction,DLLME)的研究进展及其在药物分析中的应用。方法查阅国内外文献,并进行分析和总结。结果 DLLME是一种新型样品前处理方法,具有操作简单、快速、有机溶剂消耗量少、富集倍数高等优点,受到研究者的重视。该技术发展迅速、应用广泛。结论 DLLME在药物快速分析中的应用前景广阔。Objective To review the research progress on dispersive liquid-liquid microextraction （DLLME） and its application in analysis of pharmaceuticals. Method A large number of domestic and foreign literatures were retrieved. Furthermore, the related literatures were analyzed and summarized. Result DLLME is a new sample preparation approach, which has attracted much interest from scientists working in Separation science, due to its simplicity, rapidity of operation, low consumption of solvents and higher enrichment factor. The technique has developed rapidly and has been applied to prepare samples in many fields. Conclusion DLLME is a promising approach in fast pharmaceutical analysis.

关 键 词：分散液相微萃取 药物分析 样品前处理 

分 类 号：R917[医药卫生—药物分析学]