滤除白细胞的悬浮红细胞制剂保存24小时质量评价  

Quality Evaluation of Suspending Red Cells apart from White Cells During Preservation Period of One Day

作　　者：赵颖[1] 曾娇[2] 钟利[1] 高加良[1] 万浬科[1] 张星剑 

机构地区：[1]成都市血液中心,四川成都610041 [2]成都医学院,四川成都610081 [3]眉山市人民医院,四川眉山620010

出　　处：《现代临床医学》2012年第4期264-266,共3页Journal of Modern Clinical Medicine

摘　　要：目的:研究滤除白细胞的悬浮红细胞制剂保存24小时后的质量,为临床使用滤除白细胞的悬浮红细胞制剂提供质量标准和保存依据。方法:将60份悬浮红细胞随机分为2组,对照组和实验组各30份。对照组不作处理,实验组用一次性滤器滤除白细胞。将样本置于2～8℃冰箱保存,在保存24 h时检测游离血红蛋白等5项指标的变化,比较2组数据的差别。结果:保存前滤除白细胞的悬浮红细胞制剂在24小时的保存期内各常规指标与未滤过的悬浮红细胞无显著差异。结论:为使悬浮红细胞发挥最大的临床价值,尽量使用新鲜制备的制剂,有特殊要求者应视具体情况决定。Objective：To evaluate the quality of pharmaceutical preparation of suspending red cells apart fron white cells, so as to provide quality standard and preservation basis for clinical usage of suspending red cells. Methods：Pharmaceutical preparation of suspending red cells were randomly and equally divided into experimental group and control group before preservation. Then the white cells of experimental group were filtered by disposable filter. The pharmaceutical preparations of experimental group and control group were stored in refrigerator under temperature of 2 - 8 ℃ for one day; the inspection results of routine indexes in experimental group and control group were compared. Results：No significant difference of inspection results was found between experimental group and control group within preservation period of one day. Conclusion： Newly- prepared suspending red cells should be used preferentially as far as possible to ensure maximum clinical effect if there is no special requirement.

关 键 词：悬浮红细胞 白细胞 红细胞回收率 溶血率 K+ Na+ 

分 类 号：R193.3[医药卫生—卫生事业管理]