固体酸(TiO_2/Fe^(3+))催化对硝基苯甲酸乙酯合成的研究  

The synthesis of Ethyl 4-nitrobenzoate catalyzed by TiO_2/Fe^(3+)

作　　者：盛文兵[1] 黄珍辉[1] 傅榕赓[1] 黄培[1] 彭彩云[1] 

机构地区：[1]湖南中医药大学药学院,410208

出　　处：《中国现代药物应用》2012年第15期5-6,共2页Chinese Journal of Modern Drug Application

摘　　要：目的以TiO_2/Fe^(3+)催化合成对硝基苯甲酸乙酯。方法用TiO_2/Fe^(3+)催化合成对硝基苯甲酸乙酯,产品通过MS检测,并用正交试验确定了其最佳反应条件。结果最佳反应条件为:酸醇摩尔比为1∶6,反应温度为90℃,反应时间为2h,收率达88%。结论该法能顺利实现对硝基苯甲酸和乙醇的酯化。Objective Ethyl 4-nitrobenzoate was synthesized catalyzed by TiO2/Fe3＋. Methods Eth- yl 4-nitrobenzoate was synthesized catalyzed by TiO2/Fe3＋ and tested by mass spectrum, the optimal conditions were confirmed by orthogonal tests. Results the optimal conditions were that the experiment yield is up to 88% when the temperature is 90℃, the reaction time is 2 hours, and the p-nitrohenzolc aeid：EtOH is 1：6. Conclusion TiO2/Fe3＋ can catalyze the esterification reaction effectively.

关 键 词：对硝基苯甲酸乙酯 TiO_2/Fe^3+ 酯化反应 

分 类 号：R91[医药卫生—药学]