阿托伐他汀短期强化治疗对急性冠脉综合征患者血浆sOX40L及hs-CRP浓度的影响  

Effect of statin with different dosage on concentrations of sOX40L and hs-CRP in patients with actue coronary syndrome

作　　者：刘奕[1] 宫海滨[1] 魏鹏[2] 

机构地区：[1]东南大学医学院附属徐州医院,江苏徐州221004 [2]江苏大学医学院,江苏镇江212013

出　　处：《岭南心血管病杂志》2012年第4期408-411,共4页South China Journal of Cardiovascular Diseases

基　　金：国家自然科学基金(项目编号:30572073)

摘　　要：目的研究阿托伐他汀短期强化治疗对急性冠脉综合征(acutecoronarysyndrome,ACS)患者血浆sOX40L及高敏C反应蛋白(high-sensitivety C reactive protein,hs-CRP)浓度的影响。方法 114例ACS患者按数字表法随机分为阿托伐他汀20 mg/d组、40 mg/d组和对照组,每组各38例,治疗前及治疗7 d后分别测定ACS患者血浆sOX40L,hs-CRP及血脂浓度并进行比较分析。结果治疗前各组sOX40L,hs-CRP及血脂浓度比较,差异均无统计学意义(P>0.05)。治疗7 d后阿托伐他汀20 mg/d组和40 mg/d组血浆sOX40L,hs-CRP浓度降低,与治疗前比较差异有统计学意义(P<0.05);与对照组治疗后比较,差异亦具有有统计学意义(P<0.05);40 mg/d组治疗后血浆sOX40L,hs-CRP浓度低于20 mg/d组,差异有统计学意义[sOX40L:(274.55±24.32)pg.L-1vs.(318.13±55.03)pg.L-1,P<0.05;hs-CRP:(3.02±2.55)mg.L-1vs.(4.46±1.22)mg.L-1,P<0.05]。治疗前阿托伐他汀20 mg/d组和40 mg/d组数据合并后sOX40L与hs-CRP呈正相关(r=0.712,P<0.01);治疗后阿托伐他汀两组数据合后sOX40L与hs-CRP呈正相关(r=0.748,P<0.01)。结论阿托伐他汀短期强化治疗显著降低ACS患者血浆sOX40L及hs-CRP浓度,具有明显抗炎作用。Objectives To investigate the effect of stain with different dosage on concentrations of soxg0L and high- sensitivety C reactive protein （hs-CRP） in patients with actue coronary syndrome. Methods A total of 114 patients with actue coronary syndrome were randomly assigned to low dose （20 mg）, high dose （40 mg）atovastatin and control group. Concentrations of plasma sOX40L, hs-CRP and blood lipids were detected and conpared before group and after 7 days treatment. Results Concentrations of plasma sOX40L, hs-CRP and blood lipids before treatment among the 3 groups had no significant differences （P〉0.05）. After 7 days treatment, concentrations of plasma sOX40L, bs-CRP were decreased significantly in both low dose and high dose atovastain groups while compared to those before treatment （P〈0.05）, and they were lower than that of control group after treantment （P〈0.05）. After treatment, concentrations of plasma sOX40L, hs-CRP in high dose（40 mg）atovastatin group were significantly lower than that of low dose （20 mg） atovastatin group [sOX4OL： （274.55±24.32） pg.L^-1 vs. （318.13±55.03） pg.L^-1, P〈0.05; hs-CRP： （3.02± 2.55） mg-L-1 vs. （4.46±1.22） mg-L^-1, P〈0.05]. sOX40L was positively correlated with hs-CRP when the data of the two atovastatin groups merged before treatment （r=0.712,P〈0.01）. sOX40L was positively correlated with hs-CRP when the data of the two atovastatin groups merged after treatment （r =0.748 ,P〈0.01 ）. Conclusions Plasma concentrations of OX40L and hs-CRP decreased after short term atorvastatin treatment in patients with acute coronary syndrome, and atorvastatin has obvious anti-inflammatory effect.

关 键 词：冠状动脉疾病 sOX4OL 高敏C反应蛋白 阿托伐他汀 

分 类 号：R541.4[医药卫生—心血管疾病]