MicroRNAs作为生物标志物的研究进展  

Advances of utilizing microRNAs as biomarkers

作　　者：乔靖怡[1] 金若敏[1] 

机构地区：[1]上海中医药大学药物安全评价研究中心,上海201203

出　　处：《中国中药杂志》2012年第15期2202-2205,共4页China Journal of Chinese Materia Medica

基　　金：国家重点基础研究发展计划(973)项目(2009CB522807);国家"重大新药创制"科技重大专项(2009ZX0902-002)

摘　　要：MicroRNAs(miRNAs)是一类新型的、细胞内源性的单链非编码小RNA,在细胞增殖凋亡、器官发育分化、肿瘤形成等病理生理过程中发挥重要调控作用。在血清或血浆等体液中存在的循环miRNAs由于稳定性好和特异性强等优点,提示可作为一种用于评价药物毒性致靶器官损伤的新型无创生物标志物,对药物毒性的早期监测具有重要作用。MicroRNAs（miRNAs） are a new class of endogenous,single-strand,noncoding small RNAs.MiRNAs play an important regulatory role in a variety of pathological and physiological process,such as cell proliferation and apoptosis,organ development and differentiation and tumorigenesis and so on.It has been found that circulating miRNAs are also stably and specially expressed in serum or plasma and other body fluids.Circulating miRNAs could be taken as noninvasive and new biomarkers for evaluating the drug-induced target organ injury,which may play a vital role in monitoring the drug toxicity at the early stage.

关 键 词：MICRORNAS 循环microRNAs 药物毒性 生物标志物 

分 类 号：R346[医药卫生—基础医学]