β-溶血型链球菌与银屑病发病、发生及发展的研究现状  

Current Situation of β-Hemolytic Streptococci and the Morbidity, Genesis and Development of Psoriasis

作　　者：魏迎亮[1] 郑兰艳[1] 

机构地区：[1]中国医科大学基础医学院病原生物教研室,辽宁沈阳110001

出　　处：《微生物学杂志》2012年第4期72-75,共4页Journal of Microbiology

基　　金：国家自然科学基金(81170211)

摘　　要：银屑病的发病与链球菌感染的相关性近年来得到人们的密切关注。银屑病是一类由T细胞介导的自身免疫性疾病,链球菌抗原可在易感人群中诱发或加重银屑病并使银屑病慢性持续存在。从β-溶血型链球菌诱发银屑病相关的细胞壁、细胞膜、CpG DNA序列及其他相关蛋白的自身抗原及β-溶血型链球菌通过活化T细胞、抗原抗体反应途径、通过作用机体的基因改变遗传易感性诱发银屑病的可能作用途径几方面,阐述β-溶血型链球菌与银屑病发病、发生及发展的研究现状。The reciprocity of morbidity of psoriasis and streptococcal infection have closely drawn people＇ s attention re- cently. Psoriasis is a class of T cell-mediated autoimmune diseases; the streptococcal antigen could induce or aggravate the psoriasis among susceptible press of people, or make the psoriasis to exist chronically. This article elaborated the current research situation of the morbidity, the genesis, and the development of β-hemolytic streptococci and psoriasis from β-hemolytic streptococcal-induced psoriasis related cell wall, cell membrane, CpG DNA sequence and autoantigen of other related proteins and β-hemolytic streptococci through activating T cells, antigen- antibody reaction channel, through affecting gene of organism to change genetic susceptibity to induce the possible effect channel of the psoriasis.

关 键 词：银屑病感染 β-溶血型链球菌 

分 类 号：R378.12[医药卫生—病原生物学]