中国北方汉族人群IL-8基因+394T/G多态性与急性冠脉综合征的关联性  

Association of interleukin-8 +394 T/G with acute coronary syndrome in a Han population in Northern China

作　　者：张效林[1] 张保海[1] 梁振洋[1] 孙莹[1] 冯雪瑶[1] 韩雅玲[1] 

机构地区：[1]沈阳军区总医院心内科,辽宁沈阳110084

出　　处：《心脏杂志》2012年第4期442-445,共4页Chinese Heart Journal

基　　金：军队临床高新技术重大项目资助(2010GXJS001);国家自然科学基金青年科学基金项目资助(81100135)

摘　　要：目的:观察趋化因子白介素-8(Interleukin-8,IL-8)基因单核苷酸多态性与急性冠脉综合征(acute coronarysyndrome,ACS)的相关性。方法:采用直接测序的方法对675例ACS的患者和636例对照组进行检测,分析IL-8基因+394T/G单核苷酸多态的基因型和等位基因频率的分布情况。结果:IL-8基因+394 T/G单核苷酸多态在ACS组和对照组间的分布频率皆符合Hardy-Weinberg平衡定律,IL-8基因+394 T/G单核苷酸多态三种基因型(GG型,GT型和TT型)在ACS组分布频率分别为16.9%,48.7%和34.4%,在对照组分别为18.1%,50.9%和31.0%。IL-8基因+394 T/G多态基因型和等位基因频率在正常对照组和ACS组之间无明显的相关(P>0.05)。Logistic回归校正性别、年龄、体质量指数、吸烟、高血压病、高脂血症、糖尿病等冠心病易患因素后,IL-8基因+394T/G多态与ACS的发病无相关关系。结论:在中国北方汉族人群中IL-8基因+394T/G多态与ACS发病无相关关系,IL-8基因+394 T/G多态不是ACS发病的独立危险因素。AIM： To investigate the association between IL-8 ＋ 394T/G polymorphism and acute coronary syndrome （ACS） in a Hart population in Northern China. METHODS： A case-control study was conducted in 675 patients with ACS and 636 controls with normal coronary angiograms. Polymorphic genotypes were determined by polymerase chain reaction and sequencing analysis. RESULTS： Genotype frequencies in IL-8 ＋ 394 T/G polymorphism were in good concordance with the Hardy-Weinberg equilibrium in both case and control groups. Genotype frequencies of GG, GT and TT of IL-8 ＋ 394 T/G polymorphism were 18.1%, 50. 9% and 31.0% in the controls, and 16. 9%, 48.7% and 34.4% in patients with ACS, respectively. There were no significant differences in the genotype and allele distribution of ＋ 394 T/G polymorphism of the IL-8 gene between groups （P 〉 0. 05 ）. Logistic regression analysis with adjustments for other risk factors revealed that the IL-8 ＋ 394 T/G allele carriers did not significantly increase the risks of ACS compared with noncarriers （P 〉 0. 05 ）. CONCLUSIONS ： IL-8 ＋ 394 T/G polymorphism was not a genetic risk factor for ACS in a Han population in Northern China.

关 键 词：冠状动脉疾病 急性冠脉综合征 基因 单核苷酸多态性 

分 类 号：R541.4[医药卫生—心血管疾病]