代谢综合征各组分与原发性高血压患者血压晨峰发生的相关性  

Relationship between prevalence of morning blood pressure surge and components of metabolic syndrome

作　　者：孙永超[1,2] 潘艳艳[3] 李明 路方红[1] 刘振东[1] 胡小亮[1] 

机构地区：[1]山东省医学科学院基础医学研究所心脑血管病防治中心,山东济南250062 [2]济南护理职业学院内科教研室,山东济南250062 [3]山东大学齐鲁儿童医院儿科,山东济南250062

出　　处：《心脏杂志》2012年第4期450-452,455,共4页Chinese Heart Journal

基　　金：山东省自然科学基金项目资助(ZR2009CL029);山东省医药卫生计划项目资助(2009HW080);山东省医学科学院项目资助[2010(13)]

摘　　要：目的:探讨代谢综合征(MS)各组分与原发性高血压(EH)患者血压晨峰(MBPS)发生的相关性。方法:回顾性分析了在山东省章丘市农村入选的EH患者322例,根据患者是否并发有MS将患者分为并发MS组(n=126)和单纯EH组(n=196),所有患者监测24h动态血压,比较两组患者血压晨峰发生情况。结果:并发MS组患者24hSBP、白天(d)SBP、夜间(n)SBP、24 h脉压(PP)、dPP、nPP、MBPS值均显著高于单纯EH组,差异有统计学意义(P<0.05或P<0.01)。并发MS组患者MBPS发生率为60.3%显著高于单纯EH组,差异有统计学意义(P<0.01)。Pearson相关分析显示,MBPS与年龄、空腹血糖(FPG)、总胆固醇(TC)、三酰甘油、低密度脂蛋白胆固醇、SBP、PP、体质量指数及腰围呈正相关,相关系数分别为0.38,0.44,0.48,0.26,0.35,0.38,0.34,0.21和0.43,P<0.05或P<0.01。多元线性逐步回归分析显示,TC、年龄、FPG、SBP及腰围是影响EH并发MS患者出现MBPS的主要危险因素(P<0.05或P<0.01)。结论:MS与MBPS的发生密切相关,其组分FPG、SBP及腰围是影响MBPS发生的主要危险因素。AIM： To investigate the prevalence of morning blood pressure surge （MBPS） and the compo- nents of metabolic syndrome （MetS）. METHODS ： A total of 322 patients with essential hypertension （EH） were enrolled and divided into two groups： EH and MetS group （EH ＋ MS, n = 126） and EH and non-MetS group （EH ＋ nMS, n = 196 ） and ambulatory blood pressure were recorded. RESULTS： Twenty four-hour SBP, dSBP, nSBPP, 24 h PP, dPP, nPP and MBPS were significantly higher in EH ＋ MS group than in EH ＋ nMS group （P 〈0. 05 or P 〈0. 01 ）. The incidence of morning blood pressure in EH ＋ MS group was higher than that in EH ＋ NMS group （P 〈0. 01 ）. Pearson relation analysis and multiple regression analysis showed that morning blood pressure levels were positively correlated with age, fasting plasma glucose （FPG）, total cholesterol （TC）, triglyceride （TG）, low-density lipoprotein cholesterol （LDL-C）, systolic blood pressure （SBP）, PP, body mass index （BMI） and waist circumference （WC）. After ad- justing other risk factors, TC, age, FPG, SBP and WC remained as predisposing risk factors for MBPS levels. CONCLUSION： MetS correlates closely with morning blood pressure surge. TC, age, FPG,SBP and WC are independently associated with the prevalence of morning blood pressure surge.

关 键 词：代谢综合征 高血压 原发性 血压晨峰 

分 类 号：R544.1[医药卫生—心血管疾病]