胺碘酮治疗室性心律失常对TpTe的影响  

Effect of amiodarone on TpTe interval in treatment of ventricular arrhythmias

作　　者：赵红[1] 王蔓莉[1] 李丽华[1] 顾定伟[1] 葛庆峰[1] 贾惠敏[1] 白华[1] 

机构地区：[1]河北联合大学附属医院心内科,河北唐山063000

出　　处：《心脏杂志》2012年第4期471-473,共3页Chinese Heart Journal

基　　金：河北省科技厅课题资助(072761261)

摘　　要：目的:观察胺碘酮治疗室性心律失常治疗时程对心电图T波顶点至T波终点的宽度(T-peak to T-end inter-val,TpTe)的影响。方法:85例室性心律失常患者,胺碘酮150 mg静脉注射,继以1 mg/kg,持续6 h,后减量至0.5mg/kg,持续48 h后停用,静脉胺碘酮24 h后,开始同时加用口服胺碘酮,每次0.2 g,1日3次,1周;每次0.2 g,每日2次,1周;0.2 g每日1次维持,观察用药后1、3、7、10、14、17、21 d心率、TpPe、QT、TpPe-c、QTc变化。结果:心律失常控制率达92%(78/85)。治疗有效组自治疗后第1天心率明显减慢,QT间期明显延长(P≤0.01),14 d时达最大值,后趋于平稳,但未见统计学意义差异。但整个治疗时程中胺碘酮对TpTe、TpTe-c及QTc未见有统计学意义的改变。结论:胺碘酮治疗室性心律失常不影响TpTe,TpPe独立于心率,不需要心率校正。AIM： To investigate the effect of amiodarone on T-peak to T-end interval （TpTe） in the treatment of ventricular arrhythmias. METHODS： Eighty-five patients with ventricular arrhythmias （VA） received i.v. amiodarone （1 mg/kg for 6 h） followed by 0. 5 mg/kg for 48 h after a 150-mg load- ing dose. After 24 h of i. v. amiodarone, oral amiodarone was added ： 0. 2 g rid for 1 week, 0. 2 g bid for 1 week, and a maintenance dose of 0. 2 g qd. During the process, heart rate, TpPe, QT, TpPe-c and QTc on electrocardiogram were measured at 1, 3, 7, 10, 14, 17, 21 days after amiodarone treatment. RESULTS： Effective results were observed in 78/85 patients （92%）. Amiodarone apparently slowed the heart rate and extended QT interval after the first treatment day in the effective group, but no further improvement was seen in slowing the heart rate and QT interval progressive extension during the rest of the treatment procedure. Amiodarone had no influence on TpPe, TpPe-c and QTc during the treatment procedure. CONCLUSIONS： Amiodarone treatment does not affect TpPe interval. TpPe is independent of heart rate and no heart rate correction is needed.

关 键 词：胺碘酮 T波顶点到T波终点的宽度 心律失常 室性 QT间期 

分 类 号：R541.7[医药卫生—心血管疾病]