持续性心房颤动患者心率变异性与脑钠尿肽的关系  

Correlation between heart rate variability and brain natriuretic peptide in patients with persistent atrial fibrillation

作　　者：李宏松[1] 石来新[1] 卢英民[1] 韦彩雯[1] 宋蕾[1] 李志华[1] 蔡振东[1] 

机构地区：[1]上海交通大学医学院附属新华医院(崇明)心内科,上海202150

出　　处：《心脏杂志》2012年第4期474-476,共3页Chinese Heart Journal

摘　　要：目的:探讨持续性心房颤动患者心率变异性与脑钠尿肽(BNP)的相关性。方法:入选45例持续性心房颤动患者,20例正常对照组。行24小时动态心电图检查,检测心率变异性时域指标,并行BNP测定,再分析以上两者的相关性。结果:持续性房颤患者与对照组比较,心率增快,心率变异性时域指标SDNN、RMSSD、PNN50显著增加(P<0.01);平均RR间期(RINNT)实测值与BNP呈负相关;以平均心率矫正后的有关心率变异时域指标RMSS-DDdiff和PNN50Ddiff与BNP呈正相关。结论:持续性心房颤动患者心率变异性时域参数增加,BNP受心率和心率变异性改变的影响。AIM： To investigate the correlation between heart rate variability and brain natriuretic pep- tide （BNP） in patients with persistent atrial fibrillation （AF）. METHODS： Forty-five patients with persistent AF were placed into one group and 20 patients without persistent AF were placed in the normal control group. Twenty-four hour ECG was monitored for the time domain indexes of heart rate variability, and plasma BNP concentration was tested. Correlation between the time domain indexes and plasma BNP concentration was analyzed. RESULTS： In patients with persistent AF, the heart rate increased and heart rate variability time domain indexes （SDNN, RMSSD and PNNS0） increased significantly （P 〈 0. 01 ）. The actual RINNT was negatively correlated with plasma BNP concentration. After correction with the average heart rate, heart rate variability time domain indexes （RMSSDDdiff and PNNSODdiff） were positively correlated with BNP concentration. CONCLUSION： In patients with persistent AF, the time domain parameters of heart rate variability increase and plasma BNP concentration is affected by the heart rate and the changes in heart rate variability.

关 键 词：心房颤动 心率变异性 脑钠尿肽 

分 类 号：R541.71[医药卫生—心血管疾病]