微小RNA-缺血性心脏病治疗新的靶点  

miRNAs:A novel therapeutic target in ischemic heart disease

作　　者：涂应锋[1] 王晓云[1] 卜丽红[1] 闫雪峰[1] 杨丽丽[1] 申宝忠[1] 

机构地区：[1]哈尔滨医科大学附属第四医院分子影像中心,黑龙江哈尔滨150001

出　　处：《心脏杂志》2012年第4期517-520,共4页Chinese Heart Journal

摘　　要：当前,缺血性心脏病(IHD)是世界主要死亡原因之一。IHD是指因冠状动脉不同程度的受阻引起冠状血流和心肌耗氧需求之间不平衡而导致的心肌损害,最终形成充血性心力衰竭。心脏缺血损伤后,非缺血部位的心肌出现心肌重构,如心肌间质纤维化和心肌肥厚。心肌的重构过程可使心脏功能进一步恶化,更容易诱发心律失常。微小RNA(microRNAs,miRNAs)是一类长约22个核苷酸的非编码小分子RNA,通过与靶蛋白mRNA 3'端非编码区的不完全互补结合,抑制靶mRNA转录后的表达。最近大量研究显示,miRNA在心脏病理、生理过程中发挥着重要的调控作用,尤其与心肌梗死和梗死后心脏重构的发生、发展密切相关。本文将从miRNAs在IHD中的调控作用进行阐述,并探讨以miRNAs为靶点改善IHD患者的临床转归。Ischemic heart disease （IHD） is one of the leading causes of mortality worldwide. IHD is a form of congestive heart failure resulting from the imbalance between myocardial blood supply and oxygen demand, which is caused by different degrees of coronary artery obstruction. In response to the injury, nonischemic myocardium displays signs of secondary remodeling such as interstitial fibrosis and hypertrophy of cardiac myocytes. This remodeling process further deteriorates the pump function and increases suscepti- bility to arrhythmias. MicroRNAs （miRNAs） are small, noncoding RNAs that primarily function posttran- scriptionally by interacting with the 3＇ untranslated region （UTR） of specific target mRNAs in a sequence- specific manner and regulate gene expression in a sequence-dependent manner. Recent research shows that miRNAs play important roles in the physiological and pathological processes of the heart, especially being involved in the occurrence and progress of myocardial infarction （MI） and post-MI remodeling. In this review we discuss how modulation of these miRNAs represents a promising new therapeutic strategy to improve the clinical outcome in IHD.

关 键 词：微小RNA 缺血性心脏病 治疗 

分 类 号：R541.4[医药卫生—心血管疾病]