Angiopoietin/Tie2系统在血管新生与成熟过程中的表达及意义  

Expression and significance of angiopoietin/Tie2 system in angiogenesis and vascular maturation

作　　者：衣慧[1] 王宗仁 李军昌 

机构地区：[1]第四军医大学2010级硕士研究生管理大队,陕西西安710032 [2]第四军医大学第一附属医院中医科,陕西西安710032

出　　处：《心脏杂志》2012年第4期535-538,共4页Chinese Heart Journal

基　　金：国家自然科学基金项目资助(81072972)

摘　　要：血管的新生和成熟需要经过血管内皮细胞与血管周围细胞间相互作用等一系列复杂的生物学过程,这一过程受到多种细胞因子的调控。促血管生成素(angiopoietin,Ang)是近年发现的一个与血管新生与成熟密切相关的家族,包括4个成员,即Ang1、Ang2、Ang3和Ang4,其共同的特异性受体为Tie2。Ang及受体Tie2在生理性血管形成过程中对新生血管的形成、重构及成熟发挥重要的调控作用。另有研究显示,Ang/Tie2系统也参与了缺血后再灌、肿瘤及视网膜病变等多种病理性血管的形成过程。研究Ang/Tie2系统的生物学效应以及其在血管新生与成熟过程中的表达及意义,有助于深入了解相关疾病的发病机制并为疾病的治疗提供新线索。Angiogenesis and interactions between vascular vascular maturation require endothelial cells and mural a complicated biological process through the cells. The process is affected by many types of cell factors. Recent studies have found that angiopoietin is a system that has a close relationship with neo- vascularization and vascular maturation. The system includes four members, namely, Angl, Ang2, Ang3 and Ang4, and their common receptor with specificity is Tie2. Ang and its receptor Tie 2 system are two significant factors in regulating the integrity of vessels in the process of physiological and pathological gen- eration of vessels. Ang and Tie2 system play an important role in the formation of pathological vessels such as in the process of vasoganglion growth, recirculation after ischemia, tumor and retinopathy.

关 键 词：促血管生成素 血管内皮生长因子 血管新生 血管成熟 

分 类 号：R331.32[医药卫生—人体生理学]