Critical role of Toll-like receptor signaling in NK cell activation  

作　　者：GUO Qie ZHANG Cai 

机构地区：[1]Institute of lmmunopharmacology&lmmunotherapy,School of Pharmaceutical Sciences,Shandong University,Jinan 250012,China

出　　处：《Chinese Science Bulletin》2012年第24期3192-3202,共11页

基　　金：supported by the National Natural Science Foundation of China (90713033, 30901307, and 30772497);the National Basic Research Program of China (2007CB815800)

摘　　要：Toll-like receptors (TLRs) and NK cell receptors are the most important receptor superfamilies in innate immunity. TLRs act as the sensor of external pathogens, while NK cells detect alterations in endogenous protein expression on target cells through activating and inhibitory receptors. Accumulating data has demonstrated that TLRs and NK cell receptors can coordinate and regulate each other during immune responses, which contributes to the initiation of innate response and the priming of adaptive responses. TLRs can activate NK cell function directly or with the help of accessory cells in a cytokine or cell-to-cell contact dependent manner. More understanding of the recognition of innate receptors and interactions between them may provide important insights into the design of effective strategies to combat tumor and microbial infections. In this review, we summarize how TLRs and NK cells discriminate the self or non-self components respectively. And importantly, we pay more attention to the role of TLR sig-naling in induction of NK cell activation, responses and the crosstalk between them.Toll-like receptors （TLRs） and NK cell receptors are the most important receptor superfamilies in innate immunity. TLRs act as the sensor of external pathogens, while NK cells detect alterations in endogenous protein expression on target cells through acti- vating and inhibitory receptors. Accumulating data has demonstrated that TLRs and NK cell receptors can coordinate and regulate each other during immune responses, which contributes to the initiation of innate response and the priming of adaptive responses. TLRs can activate NK cell function directly or with the help of accessory cells in a cytokine or cell-to-cell contact dependent manner. More understanding of the recognition of innate receptors and interactions between them may provide important insights into the design of effective strategies to combat tumor and microbial infections. In this review, we summarize how TLRs and NK cells discriminate the self or non-self components respectively. And importantly, we pay more attention to the role of TLR sig- naling in induction of NK cell activation, responses and the crosstalk between them.

关 键 词：TOLL样受体 NK细胞 信号通路 活化 免疫反应 细胞受体 适应性反应 微生物感染 

分 类 号：R392.1[医药卫生—免疫学]