胰岛素泵联合速效胰岛素类似物治疗糖尿病酮症酸中毒疗效观察  

To observe the clinical effect of insulin pump and insulin analogues treating on diabetic ketoacidosis

作　　者：江均贤 唐锦华 

机构地区：[1]东莞石碣医院,广东东莞523290

出　　处：《中外医疗》2012年第19期93-94,共2页China & Foreign Medical Treatment

摘　　要：目的分析胰岛素泵联合速效胰岛素类似物治疗糖尿病酮症酸中毒(diabetic ketoacidosis,DKA)的临床疗效。方法选择36例DKA患者,随机选择18例为观察组,给予胰岛素泵皮下注射,余18例患者为对照组,给予常规胰岛素静脉注射治疗治疗,观察两组控制血糖<13.8mmol/L所需时间及所需胰岛素剂量、纠正DKA所需时间及所需要的胰岛素剂量、患者住院时间,低血糖发生例数。对两组结果进行对比分析。结果观察组纠正DKA的时间明显低于对照组(P<0.01),控制血糖到低于13.8mmol/L所耗时间及胰岛素的剂量、纠正DKA所需要的剂量、住院时间、不良事件发生率两组之间比较无明显差异(P>0.05)。结论使用胰岛素泵皮下连续输注方式治疗DKA与传统的小剂量静脉胰岛素降糖效果及所用胰岛素剂量基本相仿。Objective To compare the efficacy and safety of continuous subcutaneous insulin infusion therapy with a traditional low-dose intravenous infusion therapy of regular insulin in patients with diabetic ketoacidosis. Methods Choose 36 DKA patients, randomly select 18 cases as the observation group, gave them subcutaneous injection of insulin pump therapy, the rest 18 cases as the control group, all were received conventional insulin injection therapy, Observation parameters were days of hospitalization, the duration of treatment until correction of hyperglycemia and ketoacidosis, amount of insulin administration until correction of hyper- glycemia and ketoacidosis and the number of hypoglycemic events. Results There were no statistical differences in the mean dura- tion and insulin amount of treatment until correction of hyperglycemia, mean insulin amount of treatment until correction of DKA and the length of hospital stay respectively （P〉0.05）. There was significant difference for the mean duration of treatment until cor- rection of DKA between the two groups （P〈0.01）. The duration of treatment until correction of DKA was shorter in the observation group. Conclusion The clinical effects of the two cure methods continuous subcutaneous insulin infusion pump mode and the tradi- tional low-dose intravenous insulin hypoglycemic were basically similar, the insulin dose were similar.

关 键 词：胰岛素泵 胰岛素类似物 诺和锐 酮症酸中毒 

分 类 号：R587.21[医药卫生—内分泌]