皮肤利什曼病六例临床病理分析  

Clinical and pathological analysis of six cases of cutaneous leishmaniasis

作　　者：刘排[1] 宋琳毅[2] 姜袆群[1] 沈永年[1] 陈浩[1] 孙建方[1] 

机构地区：[1]中国医学科学院北京协和医学院皮肤病研究所,南京210042 [2]苏州大学附属第一医院皮肤科

出　　处：《中华皮肤科杂志》2012年第8期586-587,共2页Chinese Journal of Dermatology

摘　　要：目的探讨皮肤利什曼病的流行病学、临床及组织病理学特点。方法收集并分析6例皮肤利什曼病患者的流行病学、临床及组织病理学资料。结果6例患者均为男性，平均发病年龄47．67岁（37-67岁），平均病程10个月（6-18个月）。皮损特点为红斑、结节、溃疡，分布于面部及四肢暴露部位。组织病理表现为感染性肉芽肿模式，组织标本中均可找到组织细胞胞质内嗜碱性小体。6例患者均具有疫区工作或旅行史。结论皮肤利什曼病的诊断主要依靠流行病资料、临床表现和组织病理学检查。Objective To analyze the epidemiological, clinical and histopathological characteristics of cutaneous leishmaniasis. Methods This study included six patients with cutaneous leishmaniasis diagnosed in the Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, over the past 10 years. The epidemiological features as well as clinical and histopathologic presentations of these patients were analyzed retrospectively. Results All of the six patients were male. The mean age at onset of skin eruptions was 47.67 （range： 37-67） years, and the mean duration of disease was 10 （range： 6-18） months. Clinical presentations included erythema, nodules and ulcers in the face and limbs. Skin biopsy revealed infection-associated granulomatous inflammation with many amastigotes （basophilic bodies） in the cytoplasm of histiocytes, which were highlighted with Giemsa stain. All the patients had a history of working at or travel to epidemic areas. Conclusion The diagnosis of cutaneous leishmaniasis mainly depends on epidemiological data, clinical manifestation and histopathologic findings.

关 键 词：皮肤利什曼病 临床表现 病理分析 组织病理学检查 流行病学 感染性肉芽肿 病理学特点 发病年龄 

分 类 号：R757.9[医药卫生—皮肤病学与性病学]