二氧化钛微囊防晒霜的研制  

Preparation of Polyelectrolyte microcapsules of TiO_2 sunscreen cream

作　　者：孟慧[1] 许勇[1] 

机构地区：[1]解放军第85医院药剂科,上海200052

出　　处：《药学实践杂志》2012年第1期38-41,共4页Journal of Pharmaceutical Practice

基　　金：南京军区医药卫生科研基金(面上课题第09ma002号)

摘　　要：目的制备含纳米二氧化钛的聚电解质微囊防晒霜,并考察制剂的结构和防晒性能。方法以碳酸钙粒子为核心,通过静电吸附原理将聚电解质4-苯乙烯磺酸钠和纳米二氧化钛交替逐层包裹在核心表面形成微囊,加入辅料,按常规方法制备防晒霜。利用扫描电镜和共聚焦显微镜观察微囊结构;防晒系数分析仪测定制剂的防晒性能。结果二氧化钛微囊外观圆整,平均粒径为(5.46±1.05)μm,微囊防晒霜防晒SPF值为30.31±2.56。结论含纳米二氧化钛的聚电解质微囊防晒霜防晒的效果优于普通二氧化钛防晒霜。Objective To investigate the preparation method, the structure and the sun protection factor （SPF） of the poly- electrolyte self-assembled mierocapsules containing TiO2 nanopartieles. Methods Calcium carbonate was used as the core, and the semipermeable membrane outside the core was made of poly （sodium 4-styrenesulfonate） （PSS） and TiO2 depositing onto the core sur- face alternately through electrostatic attraction. The morphology and the structure of the microeapsules were obtained by eonfocal laser scanning microscopy and scanning electron microscopy. The SPF was tested by SPF-290 analytical system. Results The prepared mi- croeapsules were well-shaped with a mean diameter of （5.46± 1.05 ） μm. The SPF was 30.31 ±2.56. Conclusion It was indicated that in comparison with traditional TiO2 sunscreen cream, the polyelectrolyte microeapsules containing titania had powerful absorbance of the ultraviolet rays.

关 键 词：二氧化钛 微囊 防晒系数 

分 类 号：R944[医药卫生—药剂学]