氨酚羟考酮依赖性及滥用风险分析  

Oxycodone and Acetaminophen Dependence and Abuse Risk Analysis

作　　者：马军丽[1] 逄立艳[1] 周立新[1] 张黎明[1] 

机构地区：[1]北京市药品不良反应监测中心,北京100024

出　　处：《中国药物警戒》2012年第8期476-478,共3页Chinese Journal of Pharmacovigilance

摘　　要：盐酸羟考酮是盐酸吗啡的衍生物,药理作用与吗啡相似,已有动物实验表明羟考酮与吗啡的强化效应相似,具有相同的精神依赖性潜力。在美国和澳大利亚等国,羟考酮类产品是最常被遭到转移和滥用的药品之一。虽然盐酸羟考酮的单方和复方制剂都有可能引发滥用,但在我国盐酸羟考酮的复方制剂即氨酚羟考酮是按照处方药管理,相对于按照麻醉药品管理的单方制剂流失和滥用的可能性更大。医疗机构和药品监管部门应当加强对氨酚羟考酮的管理和监测,积极避免流失和滥用的发生。Oxycodone hydrochloride is a derivative of morphine. The pharmacological effects of the oxycodone hydrochloride is similar to morphine. There has been animal experiments show that oxycodone and morphine are similar in strengthening effect, and they have the same potential for psychological dependence. In the United States and Australia, oxycodone products are one of the most common drugs being diverted and abused. Although the single and compound preparations of oxycodone hydrochloride are both likely to cause abuse, In China, oxycodone acetaminophen（oxycodone hydrochloride compound） is managed in accordance with prescription drug, so it is more likely to be lossed and abused compared to the single preparation of oxycodone hydrochloride which is managed in accordance with narcotic drugs. Medical institutions and drug regulatory departments shall strengthen the management and monitoring of oxycodone acetaminophen to prevent loss and abuse.

关 键 词：氨酚羟考酮 依赖性 滥用风险 

分 类 号：R971.1[医药卫生—药品]