112例抗高血压药品不良反应分析  

Analysis of 112 cases of Adverse Drug Reactions Induced by Antihypertensive Drugs

作　　者：李磊[1] 

机构地区：[1]合肥市第一人民医院药学部,安徽合肥230061

出　　处：《中国药物警戒》2012年第8期485-486,共2页Chinese Journal of Pharmacovigilance

基　　金：安徽省第三周期临床医学特色专科基金(卫科秘[2007]765号);合肥市第三周期医学重点学科基金(卫科[2010]224号)

摘　　要：目的探讨抗高血压药物所致不良反应的特点,促进临床安全用药。方法采用回顾性研究方法,对2007年1月～2010年12月期间我院上报的抗高血压药品不良反应(ADR)报表进行统计分析。结果我院4年间共有112例抗高血压药物ADR,占总数的5.9%;女性患者多于男性;70～90岁之间患者ADR发生最多;CCB与ACEI类ADR发生最多均为33例;严重不良反应4例,其中3例使用药物以利血平为主。结论临床医生应高度重视高血压患者特别是老年患者药物不良反应,逐渐淘汰易导致严重不良反应的抗高血压药物,根据患者基本情况,合理选择药物,减少药品不良反应发生。Objective To discuss the features of adverse drug reaction（ADP,,） induced by antihypertensive drugs in order to promote the safe drug use in clinic. Methods The ADRs induced by antihypertensive drugs were searched between Jan. 2007 and Dec. 2010 in our hospital, and statistical analysis was made. Results The statistics showed 112 cases ADR were induced by antihypertensive drugs and took 5.9% of all the ADR reports in the same period. The female cases were more than the males and the incidence between 70-90 was the highest. CCB and ACEI had more cases. The serious ADRs were 4 cases, most of which were caused by an old drug reserpine. Conclusion More attention should be paid to ADR, of antihypertensive drugs and drugs with severe ADRs should be obsoleted to reduce the ADR, s.

关 键 词：抗高血压药物 药物不良反应 

分 类 号：R994.11[医药卫生—毒理学] R972.4[医药卫生—药学]