超敏C-反应蛋白在2型糖尿病并发动脉粥样硬化中的研究  

Research on high-sensitivity C-reactive protein in type 2 diabetes patients with atherosclerosis

作　　者：张敏[1] 丁爱华[1] 王尚武[1] 

机构地区：[1]益阳市桃江县人民医院检验科,湖南益阳413400

出　　处：《临床和实验医学杂志》2012年第16期1277-1278,共2页Journal of Clinical and Experimental Medicine

摘　　要：目的探讨血清超敏C-反应蛋白(Hs-CRP)、胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白-胆固醇(LDL-C)与2型糖尿病并发动脉粥样硬化的关系。方法 150例糖尿病患者(实验组)及50例健康对照者(对照组)均采用免疫比浊法测定Hs-CRP,氧化酶法测定TG、TC、一步法测定LDL-C水平,并进行相关性分析。结果实验组Hs-CRP、TG、TC、LDL-C较对照组明显升高(P<0.001),血糖控制不良组(C组)中Hs-CRP明显高于血糖控制良好组(A组)和血糖控制一般组(B组)(P<0.01),B组高于A组(P<0.01)且与TG、TC、LDL-C正相关。结论 Hs-CRP、TG、TC、LDL-C与2型糖尿病并发动脉粥样硬化密切相关,可作为风险预测指标预测2型糖尿病并发症出现。Objective To probe into the relationship between high - sensitivity C - reactive protein （ Hs - CRP）, cholesterol （ TC ）, tri- glyceride （ TG）, low - density lipoprotein cholesterol （ LDL - C） and the emergence of atherosclerosis in patients with type 2 diabetes. Methods Hs- CRP, LDL- C, and TG and TC were detected by immunoturbidimetry, one- step method and oxidase method respectively in 150 diabetes patients （ experimental group） and 50 healthy controls （ control group）. Results The levels of Hs - CRP, TG, TC and LDL - C were significantly higher in experimental group than in the control group （ P 〈 0. 001 ）. The level of Hs - CRP in group C （ Poor blood sugar control） was obviously higher than group B（Blood sugar control general） and group A（Good blood glucose control） （ P 〈0.01） and higher in group B than group A （ P 〈 0.01 ） Hs - CRP level was positively correlated with the levels of TG, TC and LDL - C. Conclusion The levels of Hs - CRP, TG, TC and LDL - C are closely related with atberosclerosis in patients with type 2 diabetes, they can be used as risk predictors for type 2 diabetes - related ath- erosclerosis.

关 键 词：2型糖尿病 动脉粥样硬化 超敏C-反应蛋白 

分 类 号：R587.1[医药卫生—内分泌]