理想心血管健康行为和因素对高敏C反应蛋白的影响  

Effects of ideal cardiovascular health behaviors and factors on high sensitivity C-reactive protein

作　　者：王剑利[1] 吴寿岭[1] 李云[2] 朱颖[1] 陈朔华[1] 王丽晔[1] 李善廷[1] 齐海芳[1] 

机构地区：[1]河北联合大学附属开滦医院心内科,河北唐山063000 [2]河北联合大学公共卫生学院

出　　处：《中华高血压杂志》2012年第7期666-670,共5页Chinese Journal of Hypertension

摘　　要：背景最近研究显示,理想心血管健康行为和因素对心脑血管具有长期保护作用,但这种保护作用的机制尚未阐明。目的探讨理想心血管健康行为和因素对高敏C反应蛋白(hsCRP)的影响。方法采用横断面研究方法,以2008-2009年度开滦集团公司健康体检职工为研究对象,排除既往患脑梗死、心肌梗死及与本研究有关的数据和资料不全者,最终纳入统计的有效数据为79696例,进行统一问卷调查和血液生化检查,采用多因素Logistic回归分析理想心血管健康行为和因素对hsCRP的影响。结果随着理想心血管健康行为和因素数量的增多,hsCRP逐渐降低,具有0～1、2、3、4、5、6～7项理想心血管健康行为和因素的人群hsCRP中位数依次为1.70、1.60、1.50、1.30、1.01、0.90mg/L(P<0.01)。多因素Logistic回归分析表明,随着具有理想心血管健康行为和因素数量的增多,hsCRP超过3mg/L的风险逐渐下降;在校正性别、年龄、三酰甘油、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、收入水平、教育水平等危险因素后,具有6～7项理想心血管健康行为和因素的人群hsCRP超过3mg/L的风险是具有0～1项理想行为和因素人群的0.49倍(95%CI0.42～0.57,P<0.01),性别分组后女性的OR值为0.33(95%CI0.25～0.42,P<0.01),而男性的OR值为0.53(95%CI0.43～0.66,P<0.01)。结论理想心血管健康行为和因素可以降低hsCRP超过3mg/L的风险,男、女性别人群趋势相似。Background Recent studies suggest that ideal cardiovascular health behaviors and factors have long-term protective effect on cardio-cerebral vessels. However, the protective mechanism has not been clarified. Objective To explore the effects of ideal cardiovascular health behaviors and factors on the plasma level of high sensitivity C-reactive protein （hsCRP）. Methods With a cross-sectional study method, 79 696 cases who underwent Kailuan group staff physical examination between 2008 to 2009 were recruited for final analysis, when those participants with history of cerebral infarction and myocardial infarction and subjects with incomplete examination data were excluded. The same questionnaire and blood biochemical tests were conducted. And effects of ideal cardiovascular health be haviors and factors on hsCRP were analyzed by multivariate logistic regression model. Results The hsCRP concentrations decreased gradually with increasing numbers of ideal cardiovascular health behaviors and factors. The median hsCRP concentration was 1.70, 1.60, 1.50, 1.30, 1.01, 0.90 mg/L respectively in the different cohort with 0-1, 2, 3, 4, 5 and 6-7 component of ideal cardiovascular health behaviors （P〈0.01）. The risk of hsCRP exceeding 3 mg/L reduced with the increasing number of ideal health behaviors and factors by multivariate logistic re- gression analysis. And the individuals with 6 7 ideal cardiovascular health behaviors and factors bad a 0.49 fold （95% CI 0. 42--0.57, P〈0.01） risk of hsCRP exceeding 3 mg/L compared with those with 0-1 ones after adjust ment for age, gender, triglyceride low density lipoprotein-cholesterol（LDL-C）, triglyceride and high density lipoprotein-cholesterol（HDL-C）, income levels, education levels and so on. OR was 0.33 （95 % CI 0. 25- 0.42, P% 0.01 ） and 0.53 （ 95 % CI 0. 43- 0.66, P〈0.01 ） for female and male respectively. Conclusion The risk of hsCRP exceeding 3 mg/L can be reduced by ideal cardiovascular health behavior and factors. And the similar tendency is f

关 键 词：健康行为 健康因素 高敏C反应蛋白 横断面研究 

分 类 号：R54[医药卫生—心血管疾病]