普鲁卡因青霉素-硫酸双氢链霉素混悬剂对猪链球菌病的临床药效观察  

Pharmacodynamics of Procaine Penicillin-dihydrostreptomycin Sulfate Suspension against Experimentally Induced Streptococcosis suum in Pigs

作　　者：鲁晓雄[1] 贾慧勤[1] 王林[1] 赵宁[1] 丁焕中[1] 

机构地区：[1]华南农业大学兽医学院,广东省兽药研制与安全评价重点实验室,广东广州510642

出　　处：《中国畜牧兽医》2012年第7期246-249,共4页China Animal Husbandry & Veterinary Medicine

摘　　要：本研究报道了普鲁卡因青霉素-硫酸双氢链霉素混悬剂对试验性感染猪链球菌病的临床药效学。以试管2倍稀释法测得兰氏C群类马链球菌对青霉素、恩诺沙星的最小抑菌浓度(MIC)分别是0.0313、0.5mg/L。肌注给药对猪链球菌病的试验性治疗结果表明,低、中、高剂量普鲁卡因青霉素-硫酸双氢链霉素混悬剂组(0.05、0.1、0.2mL/kg体重,每毫升混悬剂含普鲁卡因青霉素、硫酸双氢链霉素200000IU和250000IU)及恩诺沙星组(2.5mg/kg体重)用药3d,对猪链球菌病的治愈率分别是60%、80%、90%及60%,而链球菌感染对照的死亡率为70%。The clinical pharmacodynamics of procaine penicillin dihydrostreptomycin sulfate suspension against Streptococ- cosis suum experimentally induced in swine was studied in this paper. Minimal inhibitory concentrations （MICs） of penicillin and enrofloxacin for Streptococcus equisilis were determined to be 0. 0313 and 0.5 mg/L by two-fold dilution method in vitro, respectively. Following the treatment with three different dosage of procaine penieillin-dihydrostreptomycin sulfate suspension （0.05 mL/kg · bw, 0.1 mL/kg · bw and 0.2 mL/kg ·bw） and enrofloxacin （2.5 mg/kg ·bw） against Streptococcosis suurn for 3 consecutive days, the curative rates of the infected swine were 60%, 80%/00,90% and 60%, respectively. The mortality of the infected but untreated group was 70%.

关 键 词：普鲁卡因青霉素 硫酸双氢链霉素 猪链球菌病 药效 

分 类 号：S858.28[农业科学—临床兽医学]