生物人工材料人工骨修复下肢骨缺损的临床观察  

Clinical observation of biological artificial material-induced artificial bone in repair of lower ex- trendty bone defects

作　　者：姚一民 檀臻炜 匡红 任翔 陈施展 汪丙昂 张聪 

机构地区：[1]解放军第四五二医院骨科,成都610021 [2]解放军第四五二医院检验科,成都610021

出　　处：《中华创伤杂志》2012年第8期708-711,共4页Chinese Journal of Trauma

基　　金：全军“十一五”课题资助项目（06G049）

摘　　要：目的观察生物人工材料（biological artificial material，BAM）人工骨修复下肢负重骨骨缺损的临床效果。方法选择2008年1月-2010年12月收治的采用BAM人工骨进行手术植入修复骨缺损的32例下肢负重骨骨缺损患者，年龄21～77岁，平均32．5岁。骨缺损体积为1．0cm×2．0cm×2．5cm-3．0cm×3．5cm×5．0cm，平均15．4cm^3。骨缺损病因主要为粉碎性骨折、骨囊肿、骨纤维结构不良、慢性骨髓炎等。术后即刻及术后1，2，3，5，7，9，12，18个月进行随访，观察术后全身及切口局部反应、血钙／磷改变情况、骨缺损修复及患肢负重功能恢复情况。结果所有患者均得到有效随访9—18个月，平均10．5个月。术后至末次随访所有患者均无局部或全身移植物排斥反应。随访X线片示术后3个月BAM人工骨植入区与骨缺损周围的骨组织之间界限模糊，有新生骨形成；术后6个月BAM人工骨植入区明显有新骨长人，人工骨材料与骨组织融为一体，骨缺损已基本修复。术后患肢完全负重时间为术后2．5～4个月，平均3．2个月。结论BAM人工骨具有良好的生物相容性和骨诱导作用，其内结构可以保持一定的刚度和强度，可用于下肢负重骨骨缺损的修复。Objective To observe the clinical effects of biological artificial material （BAM）- induced artificial bone in the repair of lower extremity bone defects. Methods The study involved 32 patients with lower extremity bone defects treated by BAM artificial bone grafting from January 2008 to December 2010. Their age was at a range of 21-77 years （mean, 32.5 years）. The volume of bone de- fects was 1.0cm×2.0cm×2.5cm-3.0cm×3.5cm×5.0cm（ mean, 15.4 cm^3 ）. The main causes of bone defects were comminuted fracture, bone cyst, fibrous dysplasia, and chronic osteomyelitis. A follow- up was performed immediately after the surgery and at 1,2, 3, 5, 7, 9, 12, 18 months after surgery to observe the systemic and local reactions, changes of blood calcium/phosphorus, repair of bone defect and restoration of function of the affected extremity. Results All patients were followed up for 9-18 months （mean, 10.5 months）. There were no local or systemic grafts rejection from the postoperative period to the last follow-up. Follow-up X-ray films showed fuzzy boundary of BAM artificial bone implantation area and bone tissues around bone defects three months postoperatively and new bone formation. Apparent bone ingrowth into the BAM artificial bone implantation area, integrated artificial bone materials and bone tissues, and basically repaired bone defects were founded six months postoperaively. The time for full weight-bearing of the affected extremity was on postoperative 2.5-4 months （mean, 3.2 months）. Con- clusion BAM artificial bone is characterized by good biocompatibility, osteogenesis effect and a certain stiffness and strength of inner structure and can be used to repair the lower extremity bone defects.

关 键 词：下肢骨 生物相容性材料 骨缺损 

分 类 号：R687.3[医药卫生—骨科学]