严重创伤患者血清中IL-6、IL-8和TNF-α的动态变化及其临床意义  

Dynamic Changes of Serum IL-6,IL-8 and TNF-α Levels in Patients with Severe Trauma

作　　者：刘畅[1] 鲍小荣[1] 申捷[1] 

机构地区：[1]复旦大学附属金山医院,上海201508

出　　处：《中国临床医学》2012年第3期230-231,共2页Chinese Journal of Clinical Medicine

摘　　要：目的:观察严重创伤后血清中白细胞介素-6(IL-6)、白细胞介素-8(IL-8)及肿瘤坏死因子-α(TNF-α)的动态变化,探讨其临床意义。方法:45例严重创伤患者入选创伤组,分别在入院的第1、第3、第5、第10、第15天检测其血清TNF-α、IL-6和IL-8的水平。20名健康体检者为对照组。将检测结果进行统计学分析。结果:与对照组比较,创伤组IL-6在损伤后第1天即升高,第3～5天达到高峰后开始逐渐下降;IL-8在损伤后第1天即升高,第3～5天达到高峰后开始逐渐下降;TNF-α在损伤后第1天即升高,随后即逐渐下降直至恢复到基础水平。结论:动态观察严重创伤患者血清中细胞因子水平的变化有助于病情的评估。Objective： To study the dynamic changes of serum interleukin 6 （IL-6）, interleukin-8 （IL-8） and tumor necrosis factor （TNF-α） in patients with severe trauma. Methods： Forty five patients with severe trauma were included（trauma group）. Twenty healthy volunteers have also been enrolled（control group）. Levels of IL-6, IL-8, and TNF-α were detected on the 1st, 3rd,Sth, 10th and 15th day after admission. Results： The serum levels of IL-6,IL-8 and TNF-α in patients with severe trauma on the 1st day were significantly higher than those in the control group. Serum levels of IL-6 and IL 8 reached the peak after 3 to 5 days and then decreased gradually. Level of TNFa in creased at the 1st day and then decreased and gradually went back to normal level. Conclusions： Observation of the dynamic changes of serum cytokines in patients with severe trauma would con tribute to the evaluation of the patient＇s condition.

关 键 词：创伤 白细胞介素-6 白细胞介素-8 肿瘤坏死因子-Α 

分 类 号：R64[医药卫生—外科学]